Antibody and T cell responses associated with experimental human malaria infection or vaccination show limited relationships (Publications)
This study examined specific antibody and T cell responses associated with experimental malaria infection or malaria vaccination, in malaria-naive human volunteers within phase I/IIa vaccine trials, w
New diagnostic tools in schistosomiasis (Publications)
Schistosomiasis is a water-based parasitic disease that affects over 250 million people. Control efforts have long been in vain, which is one reason why schistosomiasis is considered a neglected tropi
One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (Publications)
OBJECTIVE: We aimed to prospectively derive and validate a novel 1h-algorithm using high-sensitivity cardiac troponin I (hs-cTnI) for early rule-out and rule-in of acute myocardial infarction. METHODS
Opportunistic infections and immune reconstitution inflammatory syndrome in HIV-1-infected adults in the combined antiretroviral therapy era: a... (Publications)
Despite the availability of effective combined antiretroviral treatment, many patients still present with advanced HIV infection, often accompanied by an AIDS-defining disease. A subgroup of patients
A <em>Photorhabdus</em> natural product inhibits insect juvenile hormone epoxide hydrolase (Publications)
Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compoun
Clinical value of the cultural formulation interview in Pune, India (Publications)
CONTEXT: Development of the cultural formulation interview (CFI) in DSM-5 required validation for cross-cultural and global use. AIMS: To assess the overall value (OV) of CFI in the domains of feasibi
Pharmacokinetics-pharmacodynamics analysis of spiroindolone analogs and KAE609 in a murine malaria model (Publications)
Limited information is available on pharmacokinetic and pharmacodynamic (PK-PD) parameters driving the efficacy of antimalarial drugs. Our objective was to determine dose response relationship of a pa