Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin (Publications)
Acid-catalyzed transannular cyclization of the germacrene-type sesquiterpene lactone nobilin 1 was investigated with the aim of obtaining new anti-trypanosomal cadinane derivatives. The reaction was r
Health & demographic surveillance system profile: the Rufiji Health and Demographic Surveillance System (Rufiji HDSS) (Publications)
The Rufiji Health and Demographic Surveillance System (HDSS) was established in October 1998 to evaluate the impact on burden of disease of health system reforms based on locally generated data, prior
Molecular epidemiology suggests Venezuela as the origin of the dengue outbreak in Madeira, Portugal in 2012-2013 (Publications)
An explosive epidemic occurred in Madeira Island (Portugal) from October 2012 to February 2013. Published data showed that Dengue virus type 1 DENV-1) introduced from South America was the incriminate
Co-evolution of <em>Mycobacterium tuberculosis</em> and <em>Homo sapiens</em> (Publications)
The causative agent of human tuberculosis (TB), Mycobacterium tuberculosis, is an obligate pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to transmit from perso
Academic institutions and One Health: building capacity for transdisciplinary research approaches to address complex health issues at the... (Publications)
To improve health at the human, animal, and ecosystem interface, defined as One Health, training of researchers must transcend individual disciplines to develop a new process of collaboration. The tra
Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, <em>Actinoallomurus fulvus</em> MK10-036 (Publications)
Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute
In Ivorian school-age children, infection with hookworm does not reduce dietary iron absorption or systemic iron utilization, whereas afebrile... (Publications)
BACKGROUND: In sub-Saharan Africa, parasitic diseases and low bioavailable iron intake are major causes of anemia. Anemia results from inflammation, preventing iron recycling and decreasing dietary ir