Distinguishing social and cultural features of cholera in urban and rural areas of Western Kenya: implications for public health (Publications)
Abstract Urban and rural areas have distinctive health problems, which require consideration. To examine sociocultural features of cholera and its community context, a semi-structured explanatory mode
Effect of nocturnal road traffic noise exposure and annoyance on objective and subjective sleep quality (Publications)
BACKGROUND: Various epidemiological studies have found an association between noise exposure and sleep quality, but the mediating role of annoyance is unclear for this association. OBJECTIVES: To inve
Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides (Publications)
Perhydrolysis of a sterically congested multifunctional epoxide was achieved in ethereal H2 O2 with the aid of a recently developed Mo catalyst. The resulting hydroperoxide cyclized to give a 1,2,4-tr
<em>Mycobacterium tuberculosis</em> mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant... (Publications)
A key question in tuberculosis control is why some strains of M. tuberculosis are preferentially associated with resistance to multiple drugs. We demonstrate that M. tuberculosis strains from lineage
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives (Publications)
Sixty-two cationic benzyl phenyl ether derivatives (36 amidines and 26 prodrugs) were prepared and assayed for activities in vitro and in vivo against Trypanosoma brucei rhodesiense (STIB900), and in
Novel 3-nitro-1<em>H</em>-1,2,4-triazole-based piperazines a nd 2-amino-1,3-benzothiazoles as antichagasic agents (Publications)
We have previously shown that 3-nitro-1H-1,2,4-triazole-based amines demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. I
Nonrandomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing posttreatment circulation of... (Publications)
Artemisinin combination therapies eliminate immature Plasmodium falciparum gametocytes but not mature gametocytes, which may persist for up to 1 month posttreatment. A single dose of primaquine, which
UV-triggered affinity-capture identifies interactions between the <em>Plasmodium falciparum</em> multidrug resistance protein 1 (PfMDR1) and... (Publications)
A representative of a new class of potent antimalarials with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reac
