Structure-activity relationships for ferriprotoporphyrin IX association and beta-hematin inhibition by 4-aminoquinolines using experimental and <em>ab... (Publications)
In order to probe structure-activity relationships of association with ferriprotoporphyrin IX (logK) and inhibition of ?-hematin formation, a series of 4-aminoquinolines with varying substituents at t
Soil-transmitted helminth infection in South America: a systematic review and geostatistical meta-analysis (Publications)
BACKGROUND: The four common soil-transmitted helminth species-Ascaris lumbricoides, Trichuris trichiura, and the two hookworm species Ancylostoma duodenale and Necator americanus-are endemic in South
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and... (Publications)
To ascertain the structure-activity relationship of the core 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439, we compared the antimalarial activities and ADME profiles of the 1,2-dio
Timeliness and completeness of vaccination and risk factors for low and late vaccine uptake in young children living in rural southern Tanzania (Publications)
Background: We studied coverage and timeliness of vaccination and risk factors for low and delayed vaccine uptake in children aged ,2 years in rural Tanzania. Methods: We used data from a cluster surv
Genetic diversity in <em>Mycobacterium tuberculosis</em> (Publications)
Recent years have witnessed an increased appreciation of the extent and relevance of strain-to-strain variation in Mycobacterium tuberculosis. This paradigm shift can largely be attributed to an impro
