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1. Anthelminthic properties of mangostin and mangostin diacetate (Publications)

   Anthelminthic properties of mangostin and mangostin diacetate

   Pertinence:

   Few anthelminthic drugs are available for human use despite the significant burden caused by helminth infections. We studied the activities of mangostin, a major bioactive xanthone isolated from the p

2. Food-borne trematodiases (Publications)

   Food-borne trematodiases

   Pertinence:

   An estimated 750 million people are at risk of infections with food-borne trematodes, which comprise liver flukes (Clonorchis sinensis, Fasciola gigantica, Fasciola hepatica, Opisthorchis felineus, an

3. Effect of irrigated rice agriculture on Japanese encephalitis, including challenges and opportunities for integrated vector management (Publications)

   Effect of irrigated rice agriculture on Japanese encephalitis, including challenges and opportunities for integrated vector management

   Pertinence:

   Japanese encephalitis (JE) is a disease caused by an arbovirus that is spread by marsh birds, amplified by pigs, and mainly transmitted by the bite of infected Culex tritaeniorhynchus mosquitoes. The

4. Activity of artemether and mefloquine against juvenile and adult <em>Schistosoma mansoni</em> in athymic and immunocompetent NMRI mice (Publications)

   Activity of artemether and mefloquine against juvenile and adult <em>Schistosoma mansoni</em> in athymic and immunocompetent NMRI mice

   Pertinence:

   Immune effector mechanisms can enhance the activity of antischistosomal drugs. We examined the in vivo effect of single oral doses of the antimalarials artemether (400 mg/kg) and mefloquine (200 mg/kg

5. Chemotherapy for major food-borne trematodes: a review (Publications)

   Chemotherapy for major food-borne trematodes: a review

   Pertinence:

   Food-borne trematode infections, caused by liver flukes (Clonorchis, Fasciola, Opisthorchis), lung flukes (Paragonimus) and intestinal flukes (Echinostoma, Fasciolopsis, heterophyids), are significant

6. Using knowledge brokering to promote evidence-based policy-making: the need for support structures (Publications)

   Using knowledge brokering to promote evidence-based policy-making: the need for support structures

   Pertinence:

7. Environmental determinants of atopic eczema phenotypes in relation to asthma and atopic sensitization (Publications)

   Environmental determinants of atopic eczema phenotypes in relation to asthma and atopic sensitization

   Pertinence:

8. Triclabendazole and its two main metabolites lack activity against <em>Schistosoma mansoni</em> in the mouse model (Publications)

   Triclabendazole and its two main metabolites lack activity against <em>Schistosoma mansoni</em> in the mouse model

   Pertinence:

9. Evaluation of quinolone derivatives for antitrypanosomal activity (Publications)

   Evaluation of quinolone derivatives for antitrypanosomal activity

   Pertinence:

   About 160 fluoroquinolones and derivatives were tested for antitrypanosomal activity in a drug sensitivity assay followed by fluorometric evaluation. The most active quinolone compounds had IC50 value

10. Discovery of dual function acridones as a new antimalarial chemotype (Publications)

    Discovery of dual function acridones as a new antimalarial chemotype

    Pertinence:

    Preventing and delaying the emergence of drug resistance is an essential goal of antimalarial drug development. Monotherapy and highly mutable drug targets have each facilitated resistance, and both a