In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in <em>Plasmodium</em> models (Publications)
The objective of this work was to characterize the in vitro (Plasmodium falciparum) and in vivo (Plasmodium berghei) activity profile of the recently discovered lead compound SSJ-183. The molecule sho
Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X (Publications)
Neisseria meningitidis is a major cause of bacterial meningitis worldwide, especially in the African meningitis belt, and has a high associated mortality. The meningococcal serogroups A, W, and X have
Trachoma among children in community surveys from four African countries and implications of using school surveys for evaluating prevalence (Publications)
BACKGROUND: School surveys provide a convenient platform to obtain large child cohorts from multiple communities and are widely used as a proxy to determine community prevalence of neglected tropical
Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation (Publications)
STUDY OBJECTIVES: We recently proposed insufficient non-rapid eye movement sleep (NREMS) intensity to contribute to disturbed nocturnal sleep in patients with narcolepsy-cataplexy (NC). To test this h
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in <em>Toxoplasma gondii</em> (Publications)
In eukaryotic organisms, cysteine palmitoylation is an important reversible modification that impacts protein targeting, folding, stability, and interactions with partners. Evidence suggests that prot
Out-of-Africa migration and neolithic coexpansion of <em>Mycobacterium tuberculosis</em> with modern humans (Publications)
Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other cro
