Antitrypanosomal triterpenoid with an epsilon-lactone E-ring from <em>Salvia urmiensis</em> (Publications)
A new triterpenoid, urmiensolide (1), was isolated from Salvia urmiensis. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute con
Not to be missed! Differential diagnoses of common dermatological problems in returning travellers (Publications)
After systemic febrile illnesses and diarrhoea, dermatological disorders are the third most frequent health problem of returning travellers consulting travel clinics. While most travel-related dermato
Serum vitamin E concentrations at 1 year and risk of atopy, atopic dermatitis, wheezing, and asthma in childhood: the PASTURE study (Publications)
BACKGROUND: Prospective studies investigating the role of serum vitamin E concentrations during early life in the development of childhood allergies and asthma are limited. OBJECTIVE: To study the ass
Sialic acid linkage in glycosphingolipids is a molecular correlate for trafficking and delivery of extracellular cargo (Publications)
Gangliosides, glycosphingolipids containing sialic acid moieties, are well known mediators of transmembrane signaling and endocytosis at the plasma membrane. However, little is known about their preci
Survey on animal bite injuries and their management to estimate human rabies deaths in N'Djamena, Chad (Publications)
OBJECTIVE: To estimate the annual human rabies incidence as a baseline prior to mass dog vaccination campaigns in N'Djaména, Chad. METHODS: Survey of animal bites, involving 50% of all healthcare prov
Enantioselective synthesis of encecaline-derived potent antimalarial agents (Publications)
The high antiplasmodial activity of racemic benzylamines rac- and rac- stimulated the synthesis of pure enantiomers. Ellman's chiral sulfinamides (S)- and (R)- were used as chiral auxiliaries. Condens
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of... (Publications)
Replacement of the pyridine core of antimalarial 3,5-diaryl-2-aminopyridines led to the identification of a novel series of pyrazine analogues with potent oral antimalarial activity. However, other ch
Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against <em>Trypanosoma... (Publications)
A significant improvement in the treatment of trypanosomiases has been achieved with the recent development of nifurtimox-eflornithine combination therapy (NECT). As an alternative to drug combination
