High-Frequency Changes in Pilin Glycosylation Patterns during Neisseria meningitidis Serogroup a Meningitis Outbreaks in the African Meningitis Belt (Publications)
In the meningitis belt of sub-Saharan Africa, there are cyclic meningococcal epidemics that coincide with clonal waves of Neisseria meningitidis carriage and invasive disease. In the framework of long
Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the plasmodium life cycle (Publications)
Quinolines are excellent ligands for metal coordination and are deployed as drugs for malaria treatment. There is a growing body of evidence indicating that metal complexes can be conjugated with anti
Metabolism of (R)-praziquantel versus the activation of a parasite transient receptor potential melastatin ion channel (Publications)
Praziquantel (PZQ) is an essential anthelmintic drug recently established to be an activator of a Transient Receptor Potential Melastatin (TRPMPZQ) ion channel in trematode worms. Bioinformatic, mutag
A scoping review of the health co-benefits of climate mitigation strategies in South America (Publications)
The accelerated production of greenhouse gases (GHG) due to human activity has led to unprecedented global warming, making climate mitigation strategies crucial for minimizing its impacts. South Ameri
Joint effect of heat and air pollution on mortality in 620 cities of 36 countries (Publications)
Background The epidemiological evidence on the interaction between heat and ambient air pollution on mortality is still inconsistent. Objectives To investigate the interaction between heat and ambient
Swiss TPH: 30 years of R&D towards new drugs for tropical diseases (Publications)
In this special issue of CHIMIA, we highlight 30 years of research and development (R&D) at Swiss TPH, deeply grounded in partnership, towards new drugs for tropical diseases.
Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A
Ultrasonography in managing extrapulmonary tuberculosis: a randomised, controlled, parallel, superiority, open-label trial (Publications)
BACKGROUND: Patients with suspected extrapulmonary tuberculosis are often treated empirically. We hypothesized that extended Focused Assessment of Sonography for HIV and Tuberculosis (eFASH), in combi
