Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets (Publications)
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals
Bayesian spatio-temporal modeling of mortality in relation to malaria incidence in western Kenya (Publications)
INTRODUCTION: The effect of malaria exposure on mortality using health facility incidence data as a measure of transmission has not been well investigated. Health and demographic surveillance systems
Draft genome sequences of seven <em>Streptococcus agalactiae </em>strains isolated from <em>Camelus dromedarius</em> at the Horn of Africa (Publications)
We present draft whole-genome sequences of seven Streptococcus agalactiae strains isolated from Camelus dromedarius in Kenya and Somalia. These data are an extension to the group B Streptococcus (GBS)
Cohort profile: the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO): a prospective HIV cohort in rural Tanzania (Publications)
BACKGROUND: The Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) is a single-site, open and ongoing prospective cohort of people living with human immunodeficiency virus (PLWHIV) established in 2
Experience and lessons from health impact assessment guiding prevention and control of HIV/AIDS in a copper mine project, northwestern Zambia (Publications)
BACKGROUND: To avoid or mitigate potential project-related adverse health effects, the Trident copper project in Kalumbila, northwestern Zambia, commissioned a health impact assessment. HIV was identi
Urbanization is a main driver for the larval ecology of <em>Aedes</em> mosquitoes in arbovirus-endemic settings in south-eastern Côte d'Ivoire (Publications)
BACKGROUND: Failure in detecting naturally occurring breeding sites of Aedes mosquitoes can bias the conclusions drawn from field studies, and hence, negatively affect intervention outcomes. We charac
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity (Publications)
A series of 75 guanidine and 2-aminoimidazoline analogue molecules were assayed in vitro against Trypanosoma brucei rhodesiense STIB900 and Plasmodium falciparum K1. The dicationic diphenyl compounds
HIV viral load as an independent risk factor for tuberculosis in South Africa: collaborative analysis of cohort studies (Publications)
INTRODUCTION: Chronic immune activation due to ongoing HIV replication may lead to impaired immune responses against opportunistic infections such as tuberculosis (TB). We studied the role of HIV repl
