Healthcare access and quality index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a... (Publications)
BACKGROUND: National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies (Publications)
BACKGROUND: Epigenetic variations in peripheral blood have potential as biomarkers for disease. This systematic review assesses the association of lung function and chronic obstructive pulmonary disea
The adverse impact of obesity on heart rate variability is modified by a <em>NFE2L2 </em>gene variant: the SAPALDIA Cohort (Publications)
BACKGROUND: Overweight has been associated with an increase in inflammatory markers and with an imbalance in the autonomic nervous system, such as a decrease in heart rate variability (HRV). In this s
Adult onset asthma and interaction between genes and active tobacco smoking: the GABRIEL consortium (Publications)
BACKGROUND: Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify nove
Heterogeneity of obesity-asthma association disentangled by latent class analysis, the SAPALDIA cohort (Publications)
Although evidence for the heterogeneity of asthma accumulated, consensus for definitions of asthma phenotypes is still lacking. Obesity may have heterogeneous effects on various asthma phenotypes. We
Infectious diseases are associated with carotid intima media thickness in adolescence (Publications)
OBJECTIVE: Inflammatory risk factors in childhood, e.g. obesity, impact on carotid artery intima media thickness (CIMT), an early indicator of atherosclerosis. Little is known on potential infectious
Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies (Publications)
BACKGROUND: The biological mechanisms by which cleaning products and disinfectants - an emerging risk factor - affect respiratory health remain incompletely evaluated. Studying genes by environment in
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function (Publications)
HapMap imputed genome-wide association studies (GWAS) have revealed > 50 loci at which common variants with minor allele frequency > 5% are associated with kidney function. GWAS using more complete re
