Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine (Publications)
With an aim to identify a dispiro-1,2,4-trioxolane with high oral activity and good physicochemical properties, 27 derivatives of an achiral piperidine trioxolane were synthesized; most were potent an
Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides (Publications)
Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy,
European Community Respiratory Health Survey II (ECRHS II) : final report of work package (WP 7) : assessment of chemical elements on PM2.5 collected... (Publications)
The follow-up of a cohort of adults from 21 European centres of the former European Community Respiratory Health Survey (ECRHS I, 1989-1992) will examine the long-term effects of exposure to ambient a