Integral solvent-induced protein precipitation for target-engagement studies in <em>Plasmodium falciparum</em> (Publications)
The limited understanding of the mechanism of action (MoA) of several antimalarials and the rise of drug resistance toward existing malaria therapies emphasizes the need for new strategies to uncover
Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage... (Publications)
BACKGROUND: The combination antimalarial artefenomel-piperaquine failed to achieve target efficacy in a phase 2b study in Africa and Vietnam. We retrospectively evaluated whether characterizing the ph
A study protocol for a multi-country cluster randomized controlled trial of the impact of a multi-component One Health strategy to eliminate... (Publications)
BACKGROUND: Opisthorchis viverrini (OV) and soil-transmitted helminths (STH) are two of the most common helminths contributing to the Neglected Tropical Disease (NTDs) burden in the Lower Mekong Basin
Seeking and receiving hypertension and diabetes mellitus care in Tanzania (Publications)
The rapid increase in chronic non-communicable diseases (NCDs) poses a major challenge to already strained health systems in sub-Saharan Africa. This study investigates the factors associated with see
Natural variation in timing of egg hatching, response to water agitation, and bidirectional selection of early and late hatching strains of the... (Publications)
BACKGROUND: Eggs of anopheline mosquitoes hatch within a few days of laying and require high levels of humidity to survive. Assessing natural variation in egg hatching and its environmental and geneti
