Quantifying the health impacts of ambient air pollutants: recommendations of a WHO/Europe project (Publications)
OBJECTIVE: Quantitative estimates of air pollution health impacts have become an increasingly critical input to policy decisions. The WHO project "Health risks of air pollution in Europe-HRAPIE" was i
ARMADA: using motif activity dynamics to infer gene regulatory networks from gene expression data (Publications)
Analysis of gene expression data remains one of the most promising avenues toward reconstructing genome-wide gene regulatory networks. However, the large dimensionality of the problem prohibits the fi
Defining the relationship between infection prevalence and clinical incidence of<em> Plasmodium falciparum</em> malaria (Publications)
In many countries health system data remain too weak to accurately enumerate Plasmodium falciparum malaria cases. In response, cartographic approaches have been developed that link maps of infection p
A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes (Publications)
Discovery of novel drug targets may lead to improved treatment of trypanosomiasis. We characterize here 2 gene products of Trypanosoma brucei that are essential for the growth of bloodstream form para
Community awareness, use and preference for pandemic influenza vaccines in Pune, India (Publications)
Vaccination is a cornerstone of influenza prevention, but limited vaccine uptake was a problem worldwide during the 2009-2010 pandemic. Community acceptance of a vaccine is a critical determinant of i
Rapid shift toward overweight from double burden of underweight and overweight among Bangladeshi women: a systematic review and pooled analysis (Publications)
CONTEXT: Studies show there is a double burden of underweight and overweight in Bangladesh amidst a global background of increasing rates of overweight in low-income settings. OBJECTIVE: The aim of th
MMP-1 and -3 promoter variants are indicative of a common susceptibility for skin and lung aging: results from a cohort of elderly women (SALIA) (Publications)
Studies have indicated that there may be a smoking-dependent association between skin wrinkling and airflow obstruction of the lung. It was suggested that this association might be because of an under
Co-option of membrane wounding enables virus penetration into cells (Publications)
During cell entry, non-enveloped viruses undergo partial uncoating to expose membrane lytic proteins for gaining access to the cytoplasm. We report that adenovirus uses membrane piercing to induce and
