Challenges in diagnosing scrub typhus among hospitalized patients with undifferentiated fever at a national tertiary hospital in northern Vietnam (Publications)
BACKGROUND: Scrub typhus (ST) is a leading cause of non-malarial febrile illness in Southeast Asia, but evidence of its true disease burden is limited because of difficulties of making the clinical di
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
A recent report by Jennison et al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is cr
Stochastic protein alkylation by antimalarial peroxides (Publications)
Antimalarial peroxides such as the phytochemical artemisinin or the synthetic ozonides arterolane and artefenomel undergo reductive cleavage of the pharmacophoric peroxide bond by ferrous heme, releas
Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay (Publications)
BACKGROUND: Drug efficacy against kelch 13 mutant malaria parasites can be determined in vitro with the ring-stage survival assay (RSA). The conventional assay protocol reflects the exposure profile o
<em>Plasmodium</em> gametocytes display homing and vascular transmigration in the host bone marrow (Publications)
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falcipar
The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance (Publications)
BACKGROUND: A clear understanding of mosquito biology is fundamental to the control efforts of mosquito-borne diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular
A novel lineage of ceftriaxone-resistant <em>Salmonella </em>Typhi from India that is closely related to XDR <em>S</em>. Typhi found in Pakistan (Publications)
Two MDR Salmonella Typhi isolates from India were found by whole genome sequencing to be closely related to the 2016 XDR S. Typhi outbreak strain from Pakistan. The Indian isolates have no chromosomal
Morbidity associated with <em>Schistosoma mekongi </em>and concurrent helminth infection in Lao People's Democratic Republic (Publications)
In 2006, some 7 years after the halt of a multi-year schistosomiasis control programme, a study was conducted in the southern part of Lao People's Democratic Republic to determine the morbidity associ
Patients with severe schistosomiasis mekongi morbidity in southern Lao People's Democratic Republic demonstrating ongoing transmission (Publications)
Chronic infection with Schistosoma mekongi may result in severe hepatosplenic morbidity. S. mekongi control programs aimed to prevent morbidity and mortality associated with infection. We report on ei
Temporal variation of pesticide mixtures in rivers of three agricultural watersheds during a major drought in the Western Cape, South Africa (Publications)
South Africa is the leading pesticide user in Sub-Saharan Africa. However, little is known about the occurrence of pesticide mixtures in surface water and potential environmental risks in Africa. This