A new chemotype with promise against <em>Trypanosoma cruzi</em> (Publications)
Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of > /=10. The initial structure-activity relationship (SAR) indicates th
Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma (Publications)
BACKGROUND: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response
Non-randomized studies using causal-modelling may give different answers than RCTs: a meta-epidemiological study (Publications)
OBJECTIVES: To evaluate how estimated treatment effects agree between non-randomized studies using causal modelling with marginal structural models (MSM-studies) and randomized trials (RCTs). STUDY DE
Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in... (Publications)
BACKGROUND: We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducte
Contextual variation in young children's acquisition of social-emotional skills (Publications)
This study examined variation in the timing of 5,447 infants' and toddlers' reported acquisition of 12 basic social-emotional skills across and within 11 developing and developed country sites. Althou