Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts (Publications)
BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a
The locus <em>C11orf30</em> increases susceptibility to poly-sensitization (Publications)
A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the
Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort (Publications)
OBJECTIVE: Air pollution and obesity are hypothesized to contribute to accelerated lung function decline with age through their inflammatory properties. We investigated whether the previously reported
Years of life lost and morbidity cases attributable to transportation noise and air pollution: a comparative health risk assessment for Switzerland in... (Publications)
BACKGROUND: There is growing evidence that chronic exposure to transportation related noise and air pollution affects human health. However, health burden to a country of these two pollutants have bee
A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes (Publications)
BACKGROUND: Air pollutants have been linked to type 2 diabetes (T2D), hypothesized to act through inflammatory pathways and may induce interleukin-6 gene (IL6) in the airway epithelium. The cytokine i
Agreement between spirometers: a challenge in the follow-up of patients and populations? (Publications)
Background: Long-term cohort studies and lung function laboratories are confronted with the need for replacement of spirometers. Lack of agreement between spirometers might affect the longitudinal com
Variability and reproducibility of carotid structural and functional parameters assessed with transcutaneous ultrasound - results from the SAPALDIA... (Publications)
OBJECTIVE: Carotid intima media thickness (CIMT) and local stiffness are vascular biomarkers of atherosclerotic burden. We investigated the variability and reproducibility of clinically relevant struc
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function (Publications)
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 seco
Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study (Publications)
A higher incidence of asthma is reported in women compared with men, but evidence in later adulthood is limited. We aimed to determine the 20-year cumulative incidence of adult asthma in Switzerland a
Re-estimated equations for 5th percentiles of lung function variables (Letter to editors) (Publications)
In 1996 we published reference equations for the 5th percentiles of lung function parameters (FVC, FEV1, PEF, FEF25, FEF50, FEF75, FEF25-75, FEV1/FVC) as a function of age and height.1 These reference
