Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of... (Publications)
PURPOSE: Over the course of COVID-19 pandemic, evidence has accumulated that SARS-CoV-2 infections may affect multiple organs and have serious clinical sequelae, but on-site clinical examinations with
Investigation of <em>Mycobacterium ulcerans</em> glycan interactions using glycan array and surface plasmon resonance (Publications)
Many pathogenic bacteria utilize glycan-based interactions to bind to host cells. Glycan array analysis and surface plasmon resonance are glycobioanalytical techniques that have been used to investiga
Immunohistochemistry: a method to analyze<em> M. ulcerans </em>infected skin tissue (Publications)
Immunohistochemistry (IHC) is a combination of immunological, biochemical, and pathological methods to visualize the presence and distribution of specific epitopes in tissue sections. Selected antigen
Competitive ELISA for the detection and quantification of<em> Mycobacterium ulcerans </em>mycolactone (Publications)
Lipids and other hydrophobic analytes are difficult to quantify by routine immunoassays due to the need to use aqueous buffers. Here, we describe an ELISA protocol suitable for the detection of mycola
Overview: development of drugs against<em> Mycobacterium ulcerans</em> (Publications)
For many years, wide margin surgical excision of Buruli ulcer lesions has been the main approach for the treatment of Mycobacterium ulcerans disease. The WHO now recommends an eight-week course of ora
Overview: mycolactone, the macrolide toxin of <em>Mycobacterium ulcerans</em> (Publications)
The acquisition by a Mycobacterium marinum-like progenitor of a plasmid encoding enzymes for the biosynthesis of the highly potent macrolide toxin mycolactone has set off the evolution of M. ulcerans
Overview: <em>Mycobacterium ulcerans </em>disease (Buruli ulcer) (Publications)
Enhanced international research efforts since the establishment of the Global BU Initiative in 1998 by the WHO have helped to advance our understanding of the epidemiology, and pathogenesis of Mycobac
Clinical diversity and treatment results in tegumentary leishmaniasis: a European clinical report in 459 patients (Publications)
BACKGROUND: Cutaneous leishmaniasis (CL) is frequent in travellers and can involve oro-nasal mucosae. Clinical presentation impacts therapeutic management. METHODOLOGY: Demographic and clinical data f
Chronic wounds in Sierra Leone: searching for Buruli ulcer, a NTD caused b<em>y Mycobacterium ulcerans</em>, at Masanga Hospital (Publications)
BACKGROUND: Chronic wounds pose a significant healthcare burden in low- and middle-income countries. Buruli ulcer (BU), caused by Mycobacterium ulcerans infection, causes wounds with high morbidity an
