Single-dose tafenoquine to prevent relapse of <em>Plasmodium vivax</em> malaria (Publications)
BACKGROUND: Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed "r
Effect of a multidimensional physical activity intervention on body mass index, skinfolds and fitness in South African children: results from a... (Publications)
Obesity-related conditions impose a considerable and growing burden on low- and middle-income countries, including South Africa. We aimed to assess the effect of twice a 10-week multidimensional, scho
Structure–activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of<em> Haemonchus contortus</em> development (Publications)
Recently, we discovered that the registered pesticide, tolfenpyrad (TFP), unexpectedly and potently inhibits the development of L4 larval stages of the parasitic nematode Haemonchus contortus with an
Early antischistosomal leads identified from<em> in vitro</em> and<em> in vivo</em> screening of the Medicines for Malaria Venture pathogen box (Publications)
As part of the control and elimination strategy of human schistosomiasis, preventive chemotherapy relies on a single drug, praziquantel. Facing an almost dry drug development pipeline, screening the P
Antiprotozoal isoprenoids from <em>Salvia hydrangea</em> (Publications)
Fractionation of the n-hexane extract of Salvia hydrangea afforded seven isoprenoids including six new compounds (1-6) and salvadione A (7). Their structures were established by comprehensive spectros
