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1. Pharmacophore model for pentamidine analogs active against <em>Plasmodium falciparum</em> (Publications)

   Pharmacophore model for pentamidine analogs active against <em>Plasmodium falciparum</em>

   Pertinence:

   Pentamidine and its analogs constitute a class of compounds that are known to be active against Plasmodium falciparum, which causes the most dangerous malarial infection. Malaria is a widespread disea

2. Safety and efficacy of the RTS,S/AS01(E) candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a... (Publications)

   Safety and efficacy of the RTS,S/AS01(E) candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial

   Pertinence:

   BACKGROUND: The RTS,S/AS01(E) candidate malaria vaccine is being developed for immunisation of infants in Africa through the expanded programme on immunisation (EPI). 8 month follow-up data have been

3. Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites (Publications)

   Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites

   Pertinence:

   Human African trypanosomiasis (HAT), caused by the protozoan parasite Trypanosoma brucei spp., is a major health problem in sub-Saharan Africa. New drugs are urgently required for the disease. Selecti

4. Structure-activity study of pentamidine analogues as antiprotozoal agents (Publications)

   Structure-activity study of pentamidine analogues as antiprotozoal agents

   Pertinence:

   Diamidine 1 (pentamidine) and 65 analogues (2-66) have been tested for in vitro antiprotozoal activities against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, and for

5. Physical activity is inversely associated with multimorbidity in elderly men: results from the KORA-Age Augsburg Study (Publications)

   Physical activity is inversely associated with multimorbidity in elderly men: results from the KORA-Age Augsburg Study

   Pertinence:

   OBJECTIVE: Physical activity is suggested to play a key role in the prevention of several chronic diseases. However, data on the association between physical activity and multimorbidity are lacking. M

6. Advances in tuberculosis (Publications)

   Advances in tuberculosis

   Pertinence:

7. What is clinical malaria? Finding case definitions for field research in highly endemic areas (Publications)

   What is clinical malaria? Finding case definitions for field research in highly endemic areas

   Pertinence:

8. Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations (Publications)

   Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations

   Pertinence:

   Forty three cationic bisbenzofurans were synthesized either by interaction of o-hydroxyaldehydes with alpha-halogenated ketones followed by intramolecular ring closure or by a copper- or palladium-med

9. Discovery of nitroheterocycles active against African trypanosomes: in vitro screening and preliminary SAR studies (Publications)

   Discovery of nitroheterocycles active against African trypanosomes: in vitro screening and preliminary SAR studies

   Pertinence:

10. Physical activity and cardiovascular risk factors in children (Publications)

    Physical activity and cardiovascular risk factors in children

    Pertinence:

    Background A number of recent systematic reviews have resulted in changes in international recommendations for children's participation in physical activity (PA) for health. The World Health Authority