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1. Evaluation of street facilities I, II and III in Basel (Publications)

   Evaluation of street facilities I, II and III in Basel

   Pertinence:

   In June 1991 the city of Basel established the first low threshold centre (LTC) subsidized by the government after various private initiatives of "Live & Survive" aids. This low threshold facility whi

2. Methods development for epidemiologic investigations of the health effects of prolonged ozone exposure. Part II. An approach to retrospective... (Publications)

   Methods development for epidemiologic investigations of the health effects of prolonged ozone exposure. Part II. An approach to retrospective estimation of lifetime ozone exposure using a questionnaire and ambient monitoring data (California sites)

   Pertinence:

   An extensive body of data supports a relation between acute exposures to ambient ozone and the occurrence of various acute respiratory symptoms and changes in measures of lung function. In contrast, r

3. Betraying the parasite's redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal... (Publications)

   Betraying the parasite's redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties

   Pertinence:

4. Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities (Publications)

   Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities

   Pertinence:

   Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of new drugs against African sleeping sickness and Chagas' disease. Diaryl s

5. The challenge of epilepsy control in deprived settings: low compliance and high fatality rates during a community-based phenobarbital program in rural... (Publications)

   The challenge of epilepsy control in deprived settings: low compliance and high fatality rates during a community-based phenobarbital program in rural Laos

   Pertinence:

6. Relationship between <em>Mycobacterium tuberculosis</em> genotype and the clinical phenotype of pulmonary and meningeal tuberculosis (Publications)

   Relationship between <em>Mycobacterium tuberculosis</em> genotype and the clinical phenotype of pulmonary and meningeal tuberculosis

   Pertinence:

   We used large sequence polymorphisms to determine the genotypes of 397 isolates of Mycobacterium tuberculosis from human immunodeficiency virus-uninfected Vietnamese adults with pulmonary (n = 235) or

7. Marine natural products from the Turkish sponge <em>Agelas oroides</em> that inhibit the enoyl reductases from <em>Plasmodium falciparum</em>,<em>... (Publications)

   Marine natural products from the Turkish sponge <em>Agelas oroides</em> that inhibit the enoyl reductases from <em>Plasmodium falciparum</em>,<em> Mycobacterium tuberculosis</em> and <em>Escherichia coli</em>

   Pertinence:

   The type II fatty acid pathway (FAS-II) is a validated target for antimicrobial drug discovery. An activity-guided isolation procedure based on Plasmodium falciparum enoyl-ACP reductase (PfFabI) enzym

8. Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies (Publications)

   Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies

   Pertinence:

   Primin (=2-methoxy-6-pentylcyclohexa-2,5-diene-1,4-dione), a natural benzoquinone synthesized in our laboratory, was investigated for its in vitro antiprotozoal, antimycobacterial, and cytotoxic poten

9. Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of <em>Scrophularia cryptophila</em> (Publications)

   Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of <em>Scrophularia cryptophila</em>

   Pertinence:

   Resin glycosides are secondary metabolites exclusive to the convolvulaceous plants. In this study, crypthophilic acids A-C (1-3), the first resin glycosides occurring in another family (Scrophulariace

10. Characterization of <em>Trypanosoma brucei</em> isolated from lymph nodes of rats (Publications)

    Characterization of <em>Trypanosoma brucei</em> isolated from lymph nodes of rats

    Pertinence:

    Forms of Trypanosoma brucei isolated from lymph nodes of cyclically or intravenously infected rats, at different stages of infection, were morphologically compared with the corresponding bloodstream f