Expression of the MSPDBL2 antigen in a discrete subset of <em>Plasmodium falciparum</em> schizonts is regulated by GDV1 but may not be linked to... (Publications)
The Plasmodium falciparum merozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts. The potential
Validation of the emergency department-paediatric early warning score (ED-PEWS) for use in low- and middle-income countries: a multicentre... (Publications)
Early recognition of children at risk of serious illness is essential in preventing morbidity and mortality, particularly in low- and middle-income countries (LMICs). This study aimed to validate the
Egg excretion patterns of soil-transmitted helminth infections in humans following albendazole-ivermectin and albendazole treatment (Publications)
BACKGROUND: Control efforts of soil-transmitted helminthiases rely primarily on large scale administration with anthelminthic drugs. The assessment of drug efficacies and understanding of drug behavio
2,8-disubstituted-1,5-naphthyridines as dual inhibitors of <em>Plasmodium falciparum</em> phosphatidylinositol-4-kinase and hemozoin formation with... (Publications)
Structure-activity relationship studies of 2,8-disubstituted-1,5-naphthyridines, previously reported as potent inhibitors of Plasmodium falciparum (Pf) phosphatidylinositol-4-kinase β (PI4K), identifi
Genetic characterization and population structure of drug-resistant <em>Mycobacterium tuberculosis</em> isolated from Brazilian patients using... (Publications)
The present study aimed to determine the genetic diversity of isolates of Mycobacterium tuberculosis (Mtb) from presumed drug-resistant tuberculosis patients from several states of Brazil. The isolate
RAIN: machine learning-based identification for HIV-1 bNAbs (Publications)
Broadly neutralizing antibodies (bNAbs) are promising candidates for the treatment and prevention of HIV-1 infections. Despite their critical importance, automatic detection of HIV-1 bNAbs from immune
Human placental schistosomiasis-a systematic review of the literature (Publications)
BACKGROUND: Schistosome egg deposition in pregnant women may affect the placenta of infected mothers and cause placental schistosomiasis (PS). Histopathological examination of placental tissue is an i
Chemoproteomics validates selective targeting of <em>Plasmodium</em> M1 alanyl aminopeptidase as an antimalarial strategy (Publications)
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metal
The number of comorbidities as an important cofactor to ASA class in predicting postoperative outcome: an international multicentre cohort study (Publications)
BACKGROUND: Multimorbidity is a growing burden in our ageing society and is associated with perioperative morbidity and mortality. Despite several modifications to the ASA physical status classificati
