Discovery of infection associated metabolic markers in human African trypanosomiasis (Publications)
Human African trypanosomiasis (HAT) remains a major neglected tropical disease in Sub-Saharan Africa. As clinical symptoms are usually non-specific, new diagnostic and prognostic markers are urgently
Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth (Publications)
Co-infection by multiple parasites is common within individuals. Interactions between co-infecting parasites include resource competition, direct competition and immune-mediated interactions and each
Metabolic characterization of <em>Leishmania major</em> infection in activated and nonactivated macrophages (Publications)
Infection with Leishmania spp. can lead to a range of symptoms in the affected individual, depending on underlying immune-metabolic processes. The macrophage activation state hereby plays a key role.
Metabolic, immune, and gut microbial signals mount a systems response to <em>Leishmania major</em> infection (Publications)
Parasitic infections such as leishmaniasis induce a cascade of host physiological responses, including metabolic and immunological changes. Infection with Leishmania major parasites causes cutaneous l
Metabolism of (<em>R</em>)-praziquantel versus the activation of a Parasite Transient Receptor Potential Melastatin ion channel (Publications)
Praziquantel (PZQ) is an essential anthelmintic drug recently established to be an activator of a Transient Receptor Potential Melastatin (TRPM(PZQ) ) ion channel in trematode worms. Bioinformatic, mu
Opportunities and challenges for decentralised clinical trials in sub-Saharan Africa: a qualitative study (Publications)
INTRODUCTION: Digital health has gained traction in research and development, and clinical decision support systems. The COVID-19 pandemic accelerated the adoption of decentralised clinical trials (DC
Antibody and B cell responses to SARS-CoV-2 infection and vaccination: the end of the beginning (Publications)
As the COVID-19 pandemic has evolved during the past years, interactions between human immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective vaccines have complicated
The Ready-to-Go questionnaire predicts health outcomes during travel: a smartphone application-based analysis (Publications)
BACKGROUND: The Ready-To-Go (R2G) Questionnaire is a tool for rapid assessment of health risks for travel consultation. This study aims to assess the utility of the R2G Questionnaire in identifying hi
Spirometric patterns in young and middle-aged adults: a 20-year European study (Publications)
BACKGROUND: Understanding the natural history of abnormal spirometric patterns at different stages of life is critical to identify and optimise preventive strategies. We aimed to describe characterist
