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1. Cynaropicrin targets the trypanothione redox system in <em>Trypanosoma brucei</em> (Publications)

   Cynaropicrin targets the trypanothione redox system in <em>Trypanosoma brucei</em>

   Pertinence:

   In mice cynaropicrin (CYN) potently inhibits the proliferation of Trypanosoma brucei-the causative agent of Human African Trypanosomiasis-by a so far unknown mechanism. We hypothesized that CYNs ?,?-u

2. Synthesis and antiprotozoal activity of dicationic 2, 6-diphenylpyrazines and aza-analogues (Publications)

   Synthesis and antiprotozoal activity of dicationic 2, 6-diphenylpyrazines and aza-analogues

   Pertinence:

   Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.)

3. A mathematical model of the dynamics of mongolian livestock populations (Publications)

   A mathematical model of the dynamics of mongolian livestock populations

   Pertinence:

4. Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane... (Publications)

   Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives

   Pertinence:

   Various natural products with the chromane and chromene scaffold exhibit high antiprotozoal activity. The natural product encecalin (7) served as key intermediate for the synthesis of different ethers

5. Improved characterization of visual evoked potentials in multiple sclerosis by topographic analysis (Publications)

   Improved characterization of visual evoked potentials in multiple sclerosis by topographic analysis

   Pertinence:

   In multiple sclerosis (MS), the combination of visual, somatosensory and motor evoked potentials (EP) has been shown to be highly correlated with the Expanded Disability Severity Scale (EDSS) and to p

6. Mathematical models of contact patterns between age groups for predicting the spread of infectious diseases (Publications)

   Mathematical models of contact patterns between age groups for predicting the spread of infectious diseases

   Pertinence:

   The spread of an infectious disease is sensitive to the contact patterns in the population and to precautions people take to reduce the transmission of the disease. We investigate the impact that diff

7. More than one way to produce protein diversity: duplication and limited alternative splicing of an adhesion molecule gene in basal arthropods (Publications)

   More than one way to produce protein diversity: duplication and limited alternative splicing of an adhesion molecule gene in basal arthropods

   Pertinence:

   Exon duplication and alternative splicing evolved multiple times in metazoa and are of overall importance in shaping genomes and allowing organisms to produce many fold more proteins than there are ge

8. Dengue fever in children: where are we now? (Publications)

   Dengue fever in children: where are we now?

   Pertinence:

9. Höhepunkte einer Schweizer Erfolgsgeschichte (Publications)

   Höhepunkte einer Schweizer Erfolgsgeschichte

   Pertinence:

10. Cutaneous leishmaniasis in Switzerland: first experience with species-specific treatment (Publications)

    Cutaneous leishmaniasis in Switzerland: first experience with species-specific treatment

    Pertinence:

    BACKGROUND: Different species of the genus Leishmania can cause cutaneous (CL) and mucosal leishmaniasis (ML). PCR-based tests allow a rapid diagnosis and determination of the species, thereby enablin