Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale (Publications)
L-praziquantel (PZQ) pharmacokinetic data were analyzed from two relative bioavailability Phase 1 studies in adult, healthy subjects with two new oral dispersion tablet (ODT) formulations of L-PZQ adm
Seroprevalence and herd-level risk factors for seroprevalence of <em>Leptospira</em> spp. in sheep, beef cattle and deer in New Zealand (Publications)
AIMS To determine seroprevalence of Leptospira borgpetersenii serovar Hardjo and L. interrogans serovar Pomona in beef cattle, sheep and deer in New Zealand and the association between farm-level risk
Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Papua New Guinea (Publications)
BACKGROUND: In 2009, the Papua New Guinea (PNG) Department of Health adopted artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DHA-PPQ) as the first- and second-line treatments for unco
Novel high-throughput screening method using quantitative PCR to determine the antimicrobial susceptibility of <em>Orientia tsutsugamushi... (Publications)
Objectives: To develop a method to enable the large-scale antimicrobial susceptibility screening of Orientia tsutsugamushi clinical isolates, using one timepoint and one concentration of antibiotics t
Case report: concurrent sympatric scrub typhus and Japanese spotted fever in Japan (Publications)
Scrub typhus and Japanese spotted fever-both rickettsial diseases-are endemic and notifiable in Japan and may cause a fatal outcome without prompt treatment. Here we present the first case of a concur
Identifying risk of viral failure in treated HIV-infected patients using different measures of adherence: the Antiretroviral Therapy Cohort... (Publications)
Adherence to antiretroviral therapy (ART) is critical for successful treatment of Human Immunodeficiency Virus (HIV), but comparisons across settings are difficult because adherence is measured in dif
Methionine-containing rhabdopeptide/xenortide-like peptides from heterologous expression of the biosynthetic gene cluster <em>kj12ABC</em> in... (Publications)
Seven new methionine-containing rhabdopeptide/xenortide-like peptides (1-7) were identified from Escherichia coli expressing the rhabdopeptide/xenortide-like peptide biosynthetic gene cluster kj12ABC
Assessing whether universal coverage with insecticide-treated nets has been achieved: is the right indicator being used? (Publications)
BACKGROUND/METHODS: Insecticide-treated nets (ITNs) are the primary tool for malaria vector control in sub-Saharan Africa, and have been responsible for an estimated two-thirds of the reduction in the
