Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents (Publications)
The discovery of pyrrolopyrazines as potent antimalarial agents is presented, with the most effective compounds exhibiting EC50 values in the low nanomolar range against asexual blood stages of Plasmo
Multiple loci associated with indices of renal function and chronic kidney disease (Publications)
Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS
Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort (Publications)
BackgroundAlthough women with severe non-allergic asthma may represent a substantial proportion of adults with asthma in clinical practice, gender differences in the incidence of allergic and non-alle
HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction (Publications)
Reduced exposure to particulate matter with a 50% cut-off aerodynamic diameter of 10 microm (PM(10)) attenuated age-related lung function decline in our cohort, particularly in the small airways. We h
Serum bilirubin is associated with lung function in a Swiss general population sample (Publications)
Bilirubin is a strong antioxidant. Increased serum levels were associated with respiratory disease and mortality risk. We studied the association of bilirubin with lung function in the SAPALDIA cohort
Spatial variation of PM elemental compositon between and within 20 European study areas - results of the ESCAPE project (Publications)
An increasing number of epidemiological studies suggest that adverse health effects of air pollution may be related to particulate matter (PM) composition, particularly trace metals. However, we lack
Air pollution and diabetes association: modification by type 2 diabetes genetic risk score (Publications)
Exposure to ambient air pollution (AP) exposure has been linked to type 2 diabetes (T2D) risk. Evidence on the impact of T2D genetic variants on AP susceptibility is lacking. Compared to single varian
Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE) (Publications)
BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE:
Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis (Publications)
BACKGROUND: Air pollution is hypothesized to be a risk factor for diabetes. Epidemiological evidence is inconsistent and has not been systematically evaluated. OBJECTIVES: We systematically reviewed e
