Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study (Publications)
BACKGROUND: Impaired renal function is evolving as an independent marker of the risk of cardiovascular morbidity and mortality. Little is known about the prevalence of impaired renal function and its
A large-scale, consortium-based genomewide association study of asthma (Publications)
BACKGROUND: Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subt
Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population (Publications)
Background: Because of changing world demographics, the elderly population is steadily increasing. Few studies have assessed the prevalence of atopy and allergic diseases in elderly persons with objec
Circulating alpha1-antitrypsin in the general population: determinants and association with lung function (Publications)
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency associated with low AAT blood concentrations is an established genetic COPD risk factor. Less is known about the respiratory health impact of var
SOS2 and ACP1 loci identified through large-scale exome chip analysis regulate kidney development and function (Publications)
Genome-wide association studies have identified > 50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analy
Determinants of change in airway reactivity over 11 years in a population study (SAPALDIA) (Publications)
We investigated determinants of change in bronchial reactivity in SAPALDIA, a population-based cohort with wide age range (29-72 years at follow-up). The role of sex, age, atopic status, smoking and B
<em>SERPINA1</em> PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort (Publications)
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of
Improvements in PM10 exposure and reduced rates of respiratory symptoms in a cohort of Swiss adults (SAPALDIA) (Publications)
RATIONALE: Reductions in mortality following improvements in air quality were documented by several studies, and our group found, in an earlier analysis, that decreasing particulate levels attenuate l
Environmental tobacco smoke exposure and diabetes in adult never-smokers (Publications)
BACKGROUND: Active smoking has been linked to type 2 diabetes mellitus (T2DM) but only few recent studies have shown environmental tobacco smoke (ETS) to be associated with DM in never-smokers. We ass
Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies (Publications)
OBJECTIVE: To investigate the variability and determinants of menopause age in two European cohort studies, the European Respiratory Health Survey and the Swiss Air Pollution and Lung Disease in Adult
