Imidazolopiperazines: hit to lead optimization of new antimalarial agents (Publications)
Starting from a hit series from a GNF compound library collection and based on a cell-based proliferation assay of Plasmodium falciparum, a novel imidazolopiperazine scaffold was optimized. SAR for th
Potential long-term toxicity of repeated orally administered doses of artemether in rats (Publications)
Artemether, an efficacious antimalarial drug, effectively prevents patent schistosome infections and morbidity, as established in laboratory models and in clinical trials. In view of concern about the
Novel <em>Bacteroides</em> host strains for detection of human- and animal-specific bacteriophages in water (Publications)
Bacteriophages active against specific Bacteroides host strains were shown to be suitable for detection of human faecal pollution. However, the practical application of this finding is limited because
Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of beta-hematin formation (Publications)
The identification of novel scaffolds for the development of effective and safe treatments to fight malaria is urgently needed. One of the main opportunities is the discovery of new molecules from nat
Associations between home- and family-related factors and fruit juice and soft drink intake among 10- to 12-year old children: the ENERGY project (Publications)
The aim of this study is to investigate associations of family-related factors with children's fruit drink/juice and soft drink consumption. A cross-sectional survey among ten- to twelve-year-old chil
Microhabitat preferences of <em>Biomphalaria pfeifferi</em> and <em>Lymnaea natalensis</em> in a natural and a man-made habitat in southeastern... (Publications)
Schistosoma mansoni is an important human parasitic disease which is widespread throughout Africa. As Biomphalaria pfeifferi snails act as intermediate host, knowledge of their population ecology is a
Caught in action: mechanistic insights into antibody-mediated inhibition of <em>Plasmodium merozoite</em> invasion (Publications)
Apical membrane antigen 1 (AMA1) plays an essential role in host cell invasion by apicomplexan parasites. A recent study by Collins et al. investigated the mode of action of an anti-AMA1 invasion-inhi