Alkamides from <em>Anacyclus pyrethrum</em> L. and their <em>in vitro</em> antiprotozoal activity (Publications)
In our ongoing study to evaluate the antiprotozoal activity of alkamides from Asteraceae, a dichloromethane extract from the roots of Anacycluspyrethrum L. showed a moderate in vitro activity against
PCR-based verification of positive rapid diagnostic tests for intestinal protozoa infections with variable test band intensity (Publications)
Stool-based rapid diagnostic tests (RDTs) for pathogenic intestinal protozoa (e.g. Cryptosporidium spp. and Giardia intestinalis) allow for prompt diagnosis and treatment in resource-constrained setti
Cohort profile: the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO): a prospective HIV cohort in rural Tanzania (Publications)
BACKGROUND: The Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) is a single-site, open and ongoing prospective cohort of people living with human immunodeficiency virus (PLWHIV) established in 2
Steroid alkaloids from <em>Holarrhena africana</em> with strong activity against <em>Trypanosoma brucei rhodesiense</em> (Publications)
In our continued search for natural compounds with activity against Trypanosoma brucei, causative agent of human African trypanosomiasis (HAT, "sleeping sickness"), we have investigated extracts from
Prevalence of diarrhoea and risk factors among children under five years old in Mbour, Senegal: a cross-sectional study (Publications)
BACKGROUND: Diarrhoeal diseases remain an important cause of mortality and morbidity among children, particularly in low- and middle-income countries. In Senegal, diarrhoea is responsible for 15% of a
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity (Publications)
A series of 75 guanidine and 2-aminoimidazoline analogue molecules were assayed in vitro against Trypanosoma brucei rhodesiense STIB900 and Plasmodium falciparum K1. The dicationic diphenyl compounds
Experience and lessons from health impact assessment guiding prevention and control of HIV/AIDS in a copper mine project, northwestern Zambia (Publications)
BACKGROUND: To avoid or mitigate potential project-related adverse health effects, the Trident copper project in Kalumbila, northwestern Zambia, commissioned a health impact assessment. HIV was identi
The recurrent campylobacteriosis epidemic over Christmas and New Year in European countries, 2006-2014 (Publications)
OBJECTIVE: Campylobacteriosis is the most frequently reported foodborne disease in Europe with a notification rate of 71 per 100,000 population in the European Union in 2014. Surveillance data show a
Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana <em>Ancistrocladus ealaensis</em> (Publications)
Three unusual heterodimeric naphthylisoquinoline alkaloids, named ealapasamines A-C (1-3), were isolated from the leaves of the tropical plant Ancistrocladus ealaensis J. Leonard. These 'mixed', const
