Inhibition of dendritic cell maturation by malaria is dose dependent and does not require<em> Plasmodium falciparum</em> erythrocyte membrane protein... (Publications)
Red blood cells infected with Plasmodium falciparum (iRBCs) have been shown to modulate maturation of human monocyte-derived dendritic cells (DCs), interfering with their ability to activate T cells.
Antibody and T cell responses associated with experimental human malaria infection or vaccination show limited relationships (Publications)
examined specific antibody and T cell responses associated with experimental malaria infection or malaria vaccination, in malaria-naive human volunteers within phase I/IIa vaccine trials, with a view to [...] investigating inter-relationships between these types of response. Malaria infection was via 5 bites of Plasmodium falciparum-infected mosquitos, with individuals reaching patent infection by 11-12 days [...] class switching was seen from an early IgM to an IgG1-dominant response of...
Pharmacokinetics-pharmacodynamics analysis of spiroindolone analogs and KAE609 in a murine malaria model (Publications)
selected class representative. Dose-response efficacy studies were conducted in the P. berghei murine malaria model and the relationship between dose and efficacy (i.e. reduction in parasitemia) was examined [...] of 30 are likely to result in maximum reduction in parasitemia in the P. berghei mouse model of malaria. This information could be used to prioritize analogs within the same class of compounds and contribute
Design of a phase III cluster randomized trial to assess the efficacy and safety of a malaria transmission blocking vaccine (Publications)
falciparum malaria transmission targeting sexual, sporogonic, or mosquito-stage antigens (SSM-VIMT) are currently under development to reduce malaria transmission. An international group of malaria experts [...] estimates suggest that such a trial is feasible, and within the range of previously supported trials of malaria interventions, although substantial issues to implementation exist.
Diagnostic accuracy of a LAMP kit for diagnosis of imported malaria in Switzerland (Publications)
BACKGROUND: The diagnosis of acute malaria in non-endemic countries is still carried out largely by microscopic examination of thick and thin smears or rapid diagnostic tests. Low-density infections might [...] METHOD: We examined the suitability of a new loop-mediated isothermal DNA-amplification kit (LAMP) for malaria diagnosis in febrile returning travellers in comparison to qPCR and microscopic examination in a [...] non-endemic setting at the Swiss TPH.RESULTS: Among 205 complete datasets,...
Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids (Publications)
research using a publicly available screening tool to boost drug discovery. The Malaria Box, assembled by the Medicines for Malaria Venture, is a structurally diverse set of 200 druglike and 200 probelike compounds [...] screening the Malaria Box against a plethora of other parasites would enable the community to better understand the similarities and differences between them. We describe the screening of the Malaria Box and