Malaria vaccines: a toy for travelers or a tool for eradication? (Publications)
efficacy of two candidate malaria vaccines in children living in malaria-endemic areas, namely RTS,S from the circumsporozoite protein that reduced infection and clinical malaria in Mozambique, and an asexual [...] visiting malaria-endemic areas, the usefulness of the first generation of malaria vaccine(s) will be limited, since the level of protection that is foreseen is unlikely to achieve that of malaria chemop [...] reduced parasite density in Papua New Guinea, allows one to believe that a m...
Evaluation of two long synthetic merozoite surface protein 2 peptides as malaria vaccine candidates (Publications)
peptide-specific antibodies in human immune sera were associated with protection from clinical malaria. The synthetic fragments share major antigenic properties with native MSP2. Immunization of mice
Malaria: burden of disease (Publications)
large parts of the planet. The failed attempt to eradicate malaria gave way to the control policy that was followed by a huge resurgence of malaria during the late 70s and 80s. Together with the emergence [...] plasmodium species and Ross confirmed that they were transmitted by female anopheline mosquitoes, malaria remains a leading cause of morbidity and mortality worldwide. Although the areas where transmission [...] living at risk has grown to about 3 billion, and is expected to go on...
Humoral immune responses during a malaria vaccine trial in Tanzanian infants (Publications)
The development of a malaria vaccine is a priority for improved and sustained malaria control. Optimal use of a vaccine in Africa will only be achieved if it can be delivered through the Expanded Programme [...] preimmunization levels by 2 years of age and which was not associated with protection against clinical malaria. The vaccine induced no IgG antibodies against (NANP)50 or P. falciparum lysates. SPf66 stimulated
Comparative cost models of a liquid nitrogen vapor phase (LNVP) cold chain-distributed cryopreserved malaria vaccine vs. a conventional vaccine (Publications)
the costs and compare these costs to those that would be incurred in distributing a 'conventional' malaria vaccine through the EPI. Capital and recurrent costs for storage, transportation, labor, energy usage
Pan-African Training School on Mathematical Modelling of Infectious Diseases (Malaria) (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/pan-african-training-school-on-mathematical-modelling-of-infectious-diseases-malaria
infectious diseases, focusing on Malaria, at the Center of Epidemiological and Modelling Analysis (CEMA), Nairobi, Kenya. This two-week event will host 15 participants from malaria-endemic African countries and [...] epidemiology, and data science. The course will cover infectious disease modelling theory, specifically malaria, and provide hands-on experience with R programming and model simulations. Participants will apply [...] through guided projects applicable to their specific areas of...