Determining important parameters in the spread of malaria through the sensitivity analysis of a mathematical model (Publications)
We perform sensitivity analyses on a mathematical model of malaria transmission to determine the relative importance of model parameters to disease transmission and prevalence. We compile two sets of baseline [...] as the prompt diagnosis and treatment of infectious individuals) can be successful in controlling malaria
Intermittent preventive treatment for malaria in infants: a decision-support tool for sub-Saharan Africa (Publications)
clinical cases of Plasmodium falciparum malaria, hospital admissions for infection with malaria parasites and malaria-associated death for different levels of malaria transmission intensity and seasonality [...] with the severity of the malaria outcome and with transmission intensity. The decision-support tool, available on the Internet, provides estimates of the percentage of malaria-associated deaths, hospi [...] effectiveness of IPTi varies with malaria transmission intensity and seasonality....
A periodically-forced mathematical model for the seasonal dynamics of malaria in mosquitoes (Publications)
orbits of field-measurable quantities that measure malaria transmission. We integrate this model with an individual-based stochastic simulation model for malaria in humans to compare the effects of insectic [...] interventions reduce transmission and prevalence, they can lead to increased clinical malaria; and all three malaria indicators return to preintervention levels within 3 years after the interventions are [...] We describe and analyze a periodically-forced difference equation model for m...
Developmental impairments following severe falciparum malaria in children (Publications)
complications of falciparum malaria, such as multiple, prolonged or focal seizures, is not known. Thus, our objective was to investigate the long-term developmental outcome of CM and malaria with complicated seizures [...] OBJECTIVE: Neurological deficits are reported in children after cerebral malaria (CM) but little is known about the prevalence and characteristics of persisting neurocognitive consequences. The prevalence [...] y increases the risk of cognitive and behavioural problems in...
Country planning for health interventions under development: lessons from the malaria vaccine decision-making framework and implications for other new... (Publications)
development will be supported by data (e.g. malaria disease burden; roles of other malaria interventions; malaria vaccine impact; economic and financial issues; malaria vaccine efficacy, quality and safety) [...] paper describes research into the anticipated processes and data needed to inform decision making on malaria vaccines, the most advanced of which is still in phase 3 trials. From 2006 to 2008, a series of country [...] consultations in Africa led to the development of a guide to assist...
Molecular approaches to epidemiology and clinical aspects of malaria (Publications)
young children. Fundamental to the development of new tools for malaria control in humans is an increased understanding of key features of malaria infection, such as the diversity of outcome in different i [...] increase our understanding of the epidemiology and clinical manifestations of malaria, as discussed at the Molecular Approaches to Malaria conference (MAM2000), Lorne, Australia, 2-5 February 2000 [...] Malaria is a problem of global importance, responsible for 1-2 million deaths per...
