Age and seasonal variation in the transition rates and detectability of <em>Plasmodium falciparum</em> malaria (Publications)
of Plasmodium falciparum infections is unclear, although this is an important term in models of malaria transmission. It is problematical to determine the duration of infections because of the difficulty
Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzania infants: a randomised, placebo-controlled trial (Publications)
BACKGROUND: Clinical malaria and severe anaemia are major causes of paediatric hospital admission and death in many malaria-endemic settings. In the absence of an effective and affordable vaccine, control [...] were not affected by the intervention. INTERPRETATION: This new approach to malaria control reduced the rate of clinical malaria and severe anaemia by delivering an available and affordable drug through [...] assess the efficacy and safety of intermittent sulphadoxine-pyrimethamine...
Reproduction numbers in malaria and their implications (Publications)
important for analyzing the effects of interventions against malaria. This has importance for both formal modeling of malaria and for planning malaria intervention strategies in the field [...] The malariologist Lewis Wendell Hackett famously observed that, "Like chess, (malaria) is played with a few pieces, but is capable of an infinite variety of situations". This paper discusses one such piece
Is fever a good sign for clinical malaria in surveys of endemic communities? (Publications)
ic sign of clinical malaria, many Plasmodium falciparum malaria cases in endemic areas do not present with measurable temperature elevations. In a field study in Tanzania, malaria morbidity was defined [...] reported illness associated with malaria parasite densities higher than those in healthy individuals. Without diagnosis of individual episodes, prevalences of malaria-attributable morbidity of 9.8% in [...] 5-9 years of age were estimated. No illness was considered to be due to malaria in...
Coverage, adherence and costs of intermittent preventive treatment of malaria in children employing different delivery strategies in Jasikan, Ghana (Publications)
t preventive treatment of malaria in children (IPTc) involves the administration of a course of anti-malarial drugs at specified time intervals to children at risk of malaria regardless of whether or not [...] known to be infected. IPTc provides a high level of protection against uncomplicated and severe malaria, with monthly sulphadoxine-pyrimethamine plus amodiaquine (SP&AQ) and sulphadoxine-pyrimethamine
Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar (Publications)
The Roll Back Malaria strategy recommends a combination of interventions for malaria control. Zanzibar implemented artemisinin-based combination therapy (ACT) for uncomplicated malaria in late 2003 and [...] all malaria patients, while LLINs are distributed free to children under age 5 y ("under five") and pregnant women. We investigated temporal trends in Plasmodium falciparum prevalence and malaria-related [...] y) mortality decreased by 52%, 33%, and 71%, respectively. Similarly, malaria-rel...