A research agenda for malaria eradication: vector control (Publications)
variety of malaria transmission environments present in the world today. In each setting, improved control for reduction of morbidity is a necessary first step towards the long-range goal of malaria eradication
Generalized seasonal autoregressive integrated moving average models for count data with application to malaria time series with low case numbers (Publications)
The models were applied to monthly malaria case time series in a district in Sri Lanka, where malaria has decreased dramatically in recent years. RESULTS: The malaria series showed long-term changes in [...] INTRODUCTION: With the renewed drive towards malaria elimination, there is a need for improved surveillance tools. While time series analysis is an important tool for surveillance, prediction and for measuring [...] on in the series. CONCLUSIONS: G(S)ARIMA models may be particularly useful...
Modeling the public health impact of malaria vaccines for developers and policymakers (Publications)
of malaria vaccines as complements to existing interventions. However, the complexity of such models may make their outputs inaccessible to non-modeling specialists. This paper describes a Malaria Vaccine [...] BACKGROUND: Efforts to develop malaria vaccines show promise. Mathematical model-based estimates of the potential demand, public health impact, and cost and financing requirements can be used to inform [...] functionality was demonstrated by estimating the public health impact of a...
Measures of clinical malaria in field trials of interventions against <em>Plasmodium falciparum</em> (Publications)
IIb or III malaria vaccine trials were simulated corresponding to each of a pre-erythrocytic, blood stage, and anti-disease vaccine, each in a population with 80% prevalence of patent malaria infection [...] BACKGROUND: Standard methods for defining clinical malaria in intervention trials in endemic areas do not guarantee that efficacy estimates will be unbiased, and do not indicate whether the intervention [...] between morbidity and parasite density and the performance of different case...
Towards malaria elimination: a new thematic series (Publications)
launch of a new thematic series of Malaria Journal -- "Towards malaria elimination" -- creates the forum that allows carrying scientific evidence on how to achieve malaria elimination in specific endemic
Malaria surveillance-response strategies in different transmission zones of the People's Republic of China: preparing for climate change (Publications)
understanding of malaria transmission patterns in the People's Republic of China (P.R. China) is crucial for designing effective surveillance-response strategies that can guide the national malaria elimination [...] survival derived from monthly mean temperature and YRH were generated. For each decade, the final malaria prediction map was overlaid by two mask maps, in terms of number of months suitable for parasite [...] 60%. RESULTS: Considering multiple environmental factors simultaneously,...
Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial (Publications)
indicates that a combination vaccine targeting different stages of the malaria life cycle is likely to provide the most effective malaria vaccine. This trial was the first to combine two existing vaccination [...] ts were healthy, malaria naive volunteers, from Oxford. The interventions were vaccination with PEV3A alone, or PEV3A+FFM ME-TRAP. The main outcome measure was protection from malaria in a sporozoite challenge [...] stages of the P. falciparum life cycle. METHODS: This was a Phase...
Inaugural meeting of the malaria policy advisory committee to the WHO: conclusions and recommendations (Publications)
conclusions and recommendations from that meeting, as part of the newly launched Malaria Journal thematic series "WHO Malaria Policy Advisory Committee: Reports and Recommendations".Summaries are provided [...] sessions on global malaria control, drug resistance and containment, rapid diagnostic test procurement criteria, larviciding, classification of countries for elimination, estimating malaria cases and deaths [...] The Malaria Policy Advisory Committee to the World Health Organization met...
Transmission of malaria in relation to distribution and coverage of long-lasting insecticidal nets in central Côte d'Ivoire (Publications)
BACKGROUND: The use of long-lasting insecticidal nets (LLINs) is an effective malaria control strategy. However, there are challenges to achieve high coverage, such as distribution sustainability, and [...] study assessed the effect of LLINs coverage and contextual factors on entomological indicators of malaria in rural Côte d'Ivoire. METHODS: The study was carried out between July 2009 and May 2012 in three [...] of central Côte d'Ivoire. In Bozi and Yoho, LLINs were distributed free of charge...
Community response to intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea (Publications)
Africa this article aims to investigate the acceptability of intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea (PNG). METHODS: A questionnaire was administered to mothers [...] is little evidence that IPTi has negative impacts on attitudes to EPI, EPI adherence or existing malaria prevention practices. CONCLUSION: The degree of similarity between findings from the acceptability [...] health cultures, appears to be accepted easily and has little impact on...