Treatment of acute uncomplicated <em>Falciparum</em> malaria with artemether-lumefantrine in nonimmune populations: a safety, efficacy, and... (Publications)
treatment of malaria in nonimmune populations are not well defined. In this study, 165 nonimmune patients from Europe and non-malarious areas of Colombia with acute, uncomplicated falciparum malaria or mixed [...] Treatment was well tolerated; most adverse events were mild to moderate and seemed to be related to malaria. There were few serious adverse events, none of which were considered to be drug-related. No significant [...] umefantrine was effective and well tolerated in the treatment of...
Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged... (Publications)
falciparum malaria was conducted to evaluate the efficacy of the combination antimalarial CGP 56697 (artemether and benflumetol), and to compare it with chloroquine, the standard drug used for malaria treatment [...] particularly whether chloroquine may still fulfil its role as first-line drug in an area of high malaria transmission and very high levels of chloroquine resistance
Malaria: burden of disease (Publications)
large parts of the planet. The failed attempt to eradicate malaria gave way to the control policy that was followed by a huge resurgence of malaria during the late 70s and 80s. Together with the emergence [...] plasmodium species and Ross confirmed that they were transmitted by female anopheline mosquitoes, malaria remains a leading cause of morbidity and mortality worldwide. Although the areas where transmission [...] living at risk has grown to about 3 billion, and is expected to go on...
Non-stationary partition modeling of geostatistical data for malaria risk mapping (Publications)
influence geographical dependence in malaria transmission differently at different locations, introducing non-stationarity. Ignoring this characteristic in malaria spatial modeling may lead to inaccurate [...] Monte Carlo simulation. This methodology was applied to analyze malaria survey data from Mali and to produce a country-level smooth map of malaria risk [...] The most common assumption in geostatistical modeling of malaria is stationarity, that is spatial correlation is a function of the...
Synthetic GPI array to study antitoxic malaria response (Publications)
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI [...] on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria