Should deep-sequenced amplicons become the new gold-standard for analysing malaria drug clinical trials? (Publications)
used to distinguish genotyping 'noise' from real low density signals, the local epidemiology of malaria transmission, and the potential impact of genetic signals from gametocytes. Results. AmpSeq greatly
Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea (Publications)
Malaria risk is highly heterogeneous. Understanding village and household-level spatial heterogeneity of malaria risk can support a transition to spatially targeted interventions for malaria elimination [...] spatial heterogeneity of malaria risk and investigate the contribution of individual, household and environmental-level risk factors. Following a period of declining malaria prevalence, the prevalence [...] useful indicators of transmission hotspots and inform the development of tailored...
CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for <em>Plasmodium falciparum </em>malaria transmission research (Publications)
The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion of parasites commits to sexual development and [...] In summary, we believe the iGP approach developed here will greatly expedite basic and applied malaria transmission stage research.
Evaluation of different deployment strategies for larviciding to control malaria: a simulation study (Publications)
METHODS: A malaria transmission model, OpenMalaria, was used to simulate varying larviciding strategies and their impact on host-seeking mosquito densities, entomological inoculation rate (EIR) and malaria prevalence [...] BACKGROUND: Larviciding against malaria vectors in Africa has been limited to indoor residual spraying and insecticide-treated nets, but is increasingly being considered by some countries as a complementary [...] g were simulated for three transmission intensities and four...
Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S (Publications)
ns. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccine modelling, with a focus on its link to the development of policy guidance for the first licensed