La malaria importée en Suisse 1974-1976 (Publications)
month after the return from the infection area, malaria is only recognized late. The diagnosis is nevertheless relatively easy if the possibility of malaria is borne in mind [...] or not at all informed about the dangers and possible prophylaxis of infection. This is true for malaria, of which 207 cases covering the years 1974 to 1976 are studied. Most involved were people between [...] antimalarial drug. All the severe cases were in this group. A review is conducted of aspects of malaria in...
Prevalence of malaria across Papua New Guinea after initial roll-out of insecticide-treated mosquito nets (Publications)
samples were collected from all consenting household members for microscopic diagnosis of malaria. RESULTS: Malaria prevalence ranged from 0% to 49.7% with a weighted average of 12.1% (95% CI 9.5, 15.3) in [...] 0.001). Splenomegaly in children and anaemia were common morbidities attributable to malaria. CONCLUSIONS: Malaria prevalence across PNG is again at levels comparable to the 1970s. The strong association [...] OBJECTIVES: To assess the population prevalence of malaria in villages across...
Assessing the impact of next-generation rapid diagnostic tests on <em>Plasmodium falciparum</em> malaria elimination strategies (Publications)
n strategies are being considered as a means to interrupt transmission of Plasmodium falciparum malaria. However, the effectiveness of such strategies will depend on the extent to which current and future
Giant host red blood cell membrane mimicking polymersomes bind parasite proteins and malaria parasites (Publications)
we aim for a dual action with drug- and 'vaccine-like' activity against malaria. By inhibiting entry of malaria parasites into host red blood cells (RBCs) - using polymer vesicle-based (polymersome) nanomimics [...] formed with the same block copolymers as nanomimics, also bind the corresponding malaria parasite ligand and whole malaria parasites, similar to nanomimics. This was demonstrated using fluorescence imaging [...] Malaria is an infectious disease that needs to be addressed using...
Diagnostic accuracy of a LAMP kit for diagnosis of imported malaria in Switzerland (Publications)
BACKGROUND: The diagnosis of acute malaria in non-endemic countries is still carried out largely by microscopic examination of thick and thin smears or rapid diagnostic tests. Low-density infections might [...] METHOD: We examined the suitability of a new loop-mediated isothermal DNA-amplification kit (LAMP) for malaria diagnosis in febrile returning travellers in comparison to qPCR and microscopic examination in a [...] non-endemic setting at the Swiss TPH.RESULTS: Among 205 complete datasets,...
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (Publications)
Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating [...] combating malaria requires development of new, easy to administer drug combinations with broad-ranging activity against all manifestations of the disease. DSM265, a triazolopyrimidine-based inhibitor of [...] dehydrogenase (DHODH), is the first DHODH inhibitor to reach clinical...
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3,... (Publications)
were the occurrence of malaria over 12 months after dose 3 in each age category. In this final analysis, we present data for the efficacy of the booster on the occurrence of malaria. Vaccine efficacy (VE) [...] (VE) against clinical malaria was analysed by negative binomial regression and against severe malaria by relative risk reduction. This trial is registered with ClinicalTrials.gov, number NCT00866619. FINDINGS: [...] children who experienced at least one episode of severe malaria in the...