Design and pre-clinical profiling of a <em>Plasmodium falciparum</em> MSP-3 derived component for a multi-valent virosomal malaria vaccine (Publications)
BACKGROUND: Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in [...] is suitable for use in humans and represents a candidate component for a virosomal multi-valent malaria subunit vaccine
Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to <em>Plasmodium falciparum</em> and <em>P. vivax</em>: a... (Publications)
(PE) against all episodes of clinical malaria from 3 to 15 mo of age. Analysis was by modified intention to treat. The PE (compared to placebo) against clinical malaria episodes (caused by all species) was [...] No rebound in malaria morbidity was observed for 6 mo following the intervention. CONCLUSIONS: IPTi using a long half-life drug combination is efficacious for the prevention of malaria and anemia in infants [...] Intermittent preventive treatment in infants (IPTi) has been shown in...
Impact of promoting longer-lasting insecticide treatment of bed nets upon malaria transmission in a rural Tanzanian setting with pre-existing high... (Publications)
experienced extremely high malaria transmission in the 1990s. By 2001-03, following high usage rates (75% of all age groups) of untreated bed nets, a 4.2-fold reduction in malaria transmission intensity was [...] Anopheles arabiensis was only 38%. CONCLUSION: Insecticide treatment of nets reduced the intensity of malaria transmission in addition to that achieved by the untreated nets alone. Impacts were most pronounced
Estimation of heterogeneity in malaria transmission by stochastic modelling of apparent deviations from mass action kinetics (Publications)
BACKGROUND: Quantifying heterogeneity in malaria transmission is a prerequisite for accurate predictive mathematical models, but the variance in field measurements of exposure overestimates true micro [...] challenge by infectious vectors. This appears to violate the principle of mass action that is implied by malaria biology. Micro-heterogeneity may be the reason for this anomaly. It is proposed that the level of [...] exposure. METHODS: The relationship between the entomological inoculation...
MalariaSphere: a greenhouse-enclosed simulation of a natural <em>Anopheles gambiae</em> (Diptera: Culicidae) ecosystem in western Kenya (Publications)
BACKGROUND: The development and implementation of innovative vector control strategies for malaria control in Africa requires in-depth ecological studies in contained semi-field environments. This particularly [...] to significantly enhance our understanding of the behavioural and evolutionary ecology of African malaria vectors and our ability to develop and evaluate innovative control strategies. With regard to ge
Do health workers' preferences influence their practices? Assessment of providers' attitude and personal use of new treatment recommendations for... (Publications)
Tanzania changed malaria treatment policies twice within a decade. First in 2001 chloroquine (CQ) was replaced by sulfadoxine-pyrimethamine (SP) for management of uncomplicated malaria and by late 2006 [...] by enquiring which antimalarial was considered most suitable for the management of uncomplicated malaria for the three patient categories: i) children below 5; ii) older children and adults; and iii) pregnant [...] pregnant women. Practice was ascertained by asking which antimalarial was...
Dynamics of socioeconomic risk factors for neglected tropical diseases and malaria in an armed conflict (Publications)
and assessed the dynamics of socioeconomic risk factors for neglected tropical diseases (NTDs) and malaria. METHODOLOGY: The same standardized and pre-tested questionnaires were administered to the heads [...] anecdotal evidence point toward a relationship between an increased risk of suffering from NTDs and malaria and armed conflict. CONCLUSION: New research is needed to deepen our understanding of the often diffuse
Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1 (Publications)
extensive preclinical evaluation of its coiled coil peptides Tex1 was identified as promising novel malaria vaccine candidate providing the rational for a comprehensive cell biological characterization of
Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications (Publications)
in the risk of clinical malaria between the second and the third dose; during the same period, there was no significant effect in Manhica. Similarly, protection against malaria episodes was maintained [...] explanation for the difference in IPTi efficacy on clinical malaria. Combination of IPTi and ITNs may be the most cost-effective tool for malaria control currently available, and needs to be explored in current [...] (IPTi) with sulphadoxine-pyrimethamine (SP) in infants resulted in different...
Modern geographical reconnaissance of target populations in malaria elimination zones (Publications)
approaches to GR to define the spatial distribution of target populations to support contemporary malaria elimination interventions. METHODS: Three GR surveys were carried out covering the outer islands [...] priority elimination interventions, including bed net distribution, indoor residual spraying (IRS) and malaria case surveillance. Data were uploaded and analysed in customized Geographic Information System (GIS) [...] operational tool for rapidly defining the spatial distribution of target...