Strengthening surveillance systems for malaria elimination by integrating molecular and genomic data (Publications)
elimination efforts are currently going on with the objective of reducing malaria morbidity and mortality by 90% and malaria elimination in at least 35 countries by 2030. Strengthening surveillance systems [...] Unprecedented efforts in malaria control over the last 15 years have led to a substantial decrease in both morbidity and mortality in most endemic settings. However, these progresses have stalled over [...] such as polymerase chain reaction (PCR) and quantitative PCR (qPCR) are...
Health systems and global progress towards malaria elimination, 2000-2016 (Publications)
progress in malaria control in the 2000-2016 period among 105 countries. Additional analysis was performed within malaria burden groups. RESULTS: There was large heterogeneity in progress in malaria control [...] BACKGROUND: As more countries progress towards malaria elimination, a better understanding of the most critical health system features for enabling and supporting malaria control and elimination is needed. METHODS: [...] with reductions in malaria burden between 2000 and 2016. In...
Sub-national stratification of malaria risk in mainland Tanzania: a simplified assembly of survey and routine data (Publications)
Recent malaria control efforts in mainland Tanzania have led to progressive changes in the prevalence of malaria infection in children, from 18.1% (2008) to 7.3% (2017). As the landscape of malaria transmission [...] incidence and fever test positivity rate for the period 2016-2017 as well as confirmed malaria incidence and malaria positivity in pregnant women for the period 2015-2017 were obtained from routine district [...] survey malaria information was developed. This pragmatic approach can...
Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization (Publications)
accelerates and streamlines the development of vaccines. RTS,S/AS01E, the most clinically advanced malaria vaccine, has moderate efficacy in African children. In contrast, immunization with sporozoites under [...] cohorts and three African countries participating in an RTS,S/AS01E pediatric phase 3 trial and malaria-naïve individuals participating in a CPS trial. We identified both preimmunization and postimmunization
Future use-cases of vaccines in malaria control and elimination (Publications)
protection. Here we discuss the history of malaria vaccines and suggest some future use-cases for future malaria vaccines that will support achieving malaria health goals in different settings. [...] well as the development and use of new interventions. A malaria vaccine has long been considered a possible new intervention to aid malaria burden reduction. However, after decades of development, only one [...] consider the use-cases and health targets of future malaria vaccines. These must be...
The influence of jittering DHS cluster locations on geostatistical model-based estimates of malaria risk in Cameroon (Publications)
surveys such as the Demographic and Health Surveys (DHS) and the Malaria Indicator Surveys (MIS) are routinely carried out to assess the malaria risk and the coverage of related interventions. A two-stage sampling [...] the influence of jittering on the estimates of the geographical distribution of malaria risk and on the effects of malaria control interventions using data from the latest MIS in Cameroon. Methods We generated [...] geostatistical variable selection was applied to identify the...