Informing new or improved vector control tools for reducing the malaria burden in Tanzania: a qualitative exploration of perceptions of mosquitoes and... (Publications)
CONCLUSIONS: Outdoor transmission is widely accepted as an obstacle to malaria elimination. Larval source management, targeting both malaria vectors and nuisance-biting mosquitoes, is the preferred method for [...] BACKGROUND: The effectiveness of malaria prevention with long-lasting insecticidal nets and indoor residual spraying is limited by emerging insecticide resistance, evasive mosquito behaviours that include [...] to widespread environmental deterioration and lack of effective mosquito...
Fine-scale distribution of malaria mosquitoes biting or resting outside human dwellings in three low-altitude Tanzanian villages (Publications)
investigated the distribution of malaria mosquitoes biting or resting outside dwellings in three low-altitude villages in south-eastern Tanzania. The likelihood of malaria infections outdoors was also assessed [...] proportion of non-human blood-meals and absence of malaria-infected mosquitoes after 12 months of nightly trapping suggests very low-levels of outdoor malaria transmission in these villages. [...] BACKGROUND: While malaria transmission in Africa still happens primarily inside houses,...
Role of human Pegivirus infections in whole <em>Plasmodium falciparum </em>sporozoite vaccination and controlled human malaria infection in African... (Publications)
protection in African volunteers undergoing whole P. falciparum sporozoites-based malaria vaccination and controlled human malaria infections (CHMI). METHODS: HPgV-1 prevalence was quantified by RT-qPCR in plasma [...] levels among different populations pose a serious challenge to the development of an effective malaria vaccine. Co-infections are among many factors associated with immune dysfunction and sub-optimal
Predicting the impact of outdoor vector control interventions on malaria transmission intensity from semi-field studies (Publications)
important step in the development of novel vector control interventions against outdoor transmission of malaria since they provide good estimates of personal protection. However, it is often infeasible to determine [...] of semi-field data suggest that transfluthrin-treated eave ribbons are a promising tool against malaria transmission by An. arabiensis in the peridomestic area, since they provide both personal and community
Nanotechnological immunoassay for rapid label-free analysis of candidate malaria vaccines (Publications)
Malaria is a life-threatening epidemic disease with half of the world's population at risk. Although its incidence rate has fallen since 2010, this ratio dramatically stalled between 2014 and 2018. New [...] molecules in serum samples. The immunoassay successfully diagnoses humoral immune responses induced by malaria vaccine candidates and reveals the timeline and stage of the infection. We applied the newly developed [...] antibody/vaccine solutions, to blood samples from clinical trials on...
A systematic literature review of microscopy methods reported in malaria clinical trials (Publications)
Microscopy of stained blood films is essential for the diagnosis of malaria, differentiation of parasite species, and estimation of parasite density performed for assessments of antimalarial drug efficacy [...] the emergence or spread of antimalarial drug resistance. Although evidence-based guidelines for malaria microscopy methods exist, the age-old microscopy techniques for parasitological assessments are subject
A comparative evaluation of mobile medical APPS (MMAS) for reading and interpreting malaria rapid diagnostic tests (Publications)
Health Organization recommends confirmatory diagnosis by microscopy or malaria rapid diagnostic test (RDT) in patients with suspected malaria. In recent years, mobile medical applications (MMAs), which can interpret [...] falciparum blood samples at five dilutions ranging from 20 to 1000 parasites (p)/microlitre (microl) and malaria negative blood samples. The RDTs were performed in a controlled, laboratory setting by a trained [...] interpreting the Pf test line of RDTs at parasite densities...