Dramatic decreases of malaria transmission intensities in Ifakara, south-eastern Tanzania since early 2000s (Publications)
000) historically experienced moderate to high malaria transmission, mediated mostly by Anopheles gambiae and Anopheles funestus. In early 2000s, malaria transmission [Plasmodium falciparum entomological [...] outdoors in Katindiuka-ward by HLC), resulting in overall PfEIR of 0.102 ib/p/yr. Nearly 80% of malaria vectors were from Katindiuka and Mlabani wards. Anopheles gambiae densities were higher outdoors [...] Most houses had brick walls and/or iron roofs (> 90%), and 52% had screened...
Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in... (Publications)
IgG4, subclass responses. Age, site, previous malaria episodes, and baseline characteristics including antibodies to CSP and other antigens reflecting malaria exposure and maternal IgGs, nutritional status [...] anti-HBsAg antibodies induced by RTS,S/AS01E vaccination were associated with malaria protection. In contrast, higher malaria exposure at baseline and non-cytophilic IgG responses to CSP were associated [...] BACKGROUND: The RTS,S/AS01E vaccine provides partial protection against malaria...
Challenges in malaria management and a glimpse at some nanotechnological approaches (Publications)
formulate a potent malaria vaccine need to be addressed with new strategies to achieve the final goal of malaria eradication. Nanotechnology-researching and designing innovative structures at the nanoscale-is [...] the case of malaria, nanotechnology provides tools to design strategies to target drug molecules to specific stages of the parasite, treat drug-resistant parasites, resolve severe malaria, increase vaccine [...] vaccine efficacies and combinations thereof. This chapter introduces mala...
Identification of fast-acting 2,6-disubstituted imidazopyridines that are efficacious in the <em>In Vivo</em> humanized <em>Plasmodium falciparum</em>... (Publications)
Optimization of a chemical series originating from whole-cell phenotypic screening against the human malaria parasite, Plasmodium falciparum, led to the identification of two promising 2,6-disubstituted im [...] properties, translated to in vivo efficacy with clearance of parasites in the PfSCID mouse model for malaria within 48 h of treatment.
Appropriateness of malaria diagnosis and treatment for fever episodes according to patient history and anti-malarial blood measurement: a... (Publications)
survey took place between May and August 2015 in three regions of Tanzania with different levels of malaria endemicity. Interviews were conducted and blood samples were collected by dried blood spots through [...] testing when individuals attended care was defined as a patient with history of fever being tested for malaria and appropriate treatment as (i) having anti-malarial in the blood if the test result was positive [...] care and improve compliance to test result in order to target febrile...
Malaria and the 'last' parasite: how can technology help? (Publications)
Malaria, together with HIV/AIDS, tuberculosis and hepatitis are the four most deadly infectious diseases globally. Progress in eliminating malaria has saved millions of lives, but also creates new challenges [...] accurate detection of malaria infections, both in symptomatic and asymptomatic individuals are needed. In this review, the current progress in developing new diagnostic tools to fight malaria is presented. An [...] An ideal rapid test for malaria elimination is envisioned with examples...