A recombinant blood-stage malaria vaccine reduces<em> Plasmodium falciparum</em> density and exerts selective pressure on parasite populations in a... (Publications)
The malaria vaccine Combination B comprises recombinant Plasmodium falciparum ring-infected erythrocyte surface antigen and 2 merozoite surface proteins (MSP1 and MSP2) formulated in oil-based adjuvant [...] demonstrate functional activity of Combination B against P. falciparum in individuals with previous malaria exposure. The specific effects on parasites with particular msp2 genotypes suggest that the MSP2
Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif (Publications)
To identify malaria antigens for vaccine development, we selected alpha-helical coiled coil domains of proteins predicted to be present in the parasite erythrocytic stage. The corresponding synthetic peptides [...] various prevalence. Peptide specific antibodies were obtained both by affinity-purification from malaria immune sera and by immunization of mice. These antibodies did not show significant cross reactions
<em>Plasmodium falciparum</em>: malaria morbidity is associated with specific merozoite surface antigen 2 genotypes (Publications)
vaccine against blood stage malaria. In order to test if a specific genotype of the highly polymorphic MSA2 is associated with disease, we conducted a case-control study in a malaria endemic area of Papua New [...] as likely to be found in symptomatic malaria cases than in asymptomatic controls. Mixed genotype infections were significantly less frequent in symptomatic malaria infections. One individual allele (WOS10) [...] to lack of immunity to it. This study provides evidence that MSA2 is...
<em>Plasmodium falciparum</em>: extensive polymorphism in merozoite surface antigen 2 alleles in an area with endemic malaria in Papua New Guinea (Publications)
falciparum: Extensive polymorphism in merozoite surface antigen 2 alleles in an area with endemic malaria in Papua New Guinea. Experimental Parasitology 79, 106-116. The prevalence of Plasmodium falciparum