Recherche de malaria.

1. Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and... (Publications)

   Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and constraints

   Pertinence:

   BACKGROUND: Rectal artesunate, an efficacious pre-referral treatment for severe malaria in children, was deployed at scale in Uganda, Nigeria, and DR Congo. In addition to distributing rectal artesunate [...] tion required additional investments in crucial but neglected components in the care for severe malaria. We examined the real-world costs and constraints to rectal artesunate implementation. METHODS: We [...] annual cost of rectal artesunate implementation per child younger than 5 years at...

2. The troubled puberty of malaria parasites (Publications)

   The troubled puberty of malaria parasites

   Pertinence:

   Sexual differentiation of malaria parasites is essential for transmission, yet the underlying mechanisms are poorly understood. Russell et al. elegantly combined a loss-of-function screen with single-cell

3. Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and <em>in vivo</em> efficacy in a... (Publications)

   Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and <em>in vivo</em> efficacy in a <em>Plasmodium berghei </em>mouse malaria infection model

   Pertinence:

   Iterative medicinal chemistry optimization of an ester-containing astemizole (AST) analogue 1 with an associated metabolic instability liability led to the identification of a highly potent 3-trifluor

4. New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies (Publications)

   New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies

   Pertinence:

   MMV’s Malaria Box compound MMV030666 shows multi-stage activity against various strains of Plasmodium falciparum and lacks resistance development. To evaluate the importance of its diarylether partial

5. Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions (Publications)

   Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions

   Pertinence:

   targeted reductions in malaria prevalence. METHODS: A mathematical model of malaria transmission dynamics is used to simulate deployment and predict potential impact of new malaria interventions by considering [...] mathematical models of malaria dynamics coupled with machine learning. Our analysis identifies requirements of efficacy, coverage, and duration of effect for five novel malaria interventions to achieve [...] achieve specified health goals. RESULTS: We apply our approach to five malar...

6. Rethinking human resources and capacity building needs for malaria control and elimination in Africa (Publications)

   Rethinking human resources and capacity building needs for malaria control and elimination in Africa

   Pertinence:

   considerable success in controlling malaria worldwide, progress toward achieving malaria elimination has largely stalled. In particular, strategies to overcome roadblocks in malaria control and elimination in Africa [...] Africa are critical to achieving worldwide malaria elimination goals—this continent carries 94% of the global malaria case burden. To identify key areas for targeted efforts, we combined a comprehensive [...] ve review of current literature with direct feedback gathered from...

7. Scalable process for high-yield production of PfCyRPA using insect cells for inclusion in a malaria virosome-based vaccine candidate (Publications)

   Scalable process for high-yield production of PfCyRPA using insect cells for inclusion in a malaria virosome-based vaccine candidate

   Pertinence:

   been identified as a promising blood-stage candidate antigen to include in a broadly cross-reactive malaria vaccine. In the last couple of decades, substantial effort has been committed to the development [...] aiming to develop a scalable, high-yield, and high-quality PfCyRPA for inclusion in a virosome-based malaria vaccine candidate. Supplements with antioxidants improved PfCyRPA volumetric titers by 50% when added

8. Treatment seeking and case management for suspected severe malaria in the context of implementing rectal artesunate (Publications)

   Treatment seeking and case management for suspected severe malaria in the context of implementing rectal artesunate

   Pertinence:

9. Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria... (Publications)

   Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria and Uganda

   Pertinence:

   artesunate (RAS) require urgent referral to a health facility where appropriate treatment for severe malaria can be provided. However, the rapid improvement of a child's condition after RAS administration may [...] completion is limited. METHODS: An observational study accompanied the roll-out of RAS in three malaria endemic settings in the Democratic Republic of the Congo (DRC), Nigeria and Uganda. Community health [...] health workers and primary health centres enrolled children under 5 years...

10. The phylodynamic and spread of the invasive Asian malaria vectors, <em>Anopheles stephensi</em>, in Sudan (Publications)

    The phylodynamic and spread of the invasive Asian malaria vectors, <em>Anopheles stephensi</em>, in Sudan

    Pertinence:

    Anopheles stephensi is an invasive Asian malaria vector that initially emerged in Africa in 2012 and was reported in Sudan in 2019. We investigated the distribution and population structure of An. stephensi