<em>In vitro</em> antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria (Publications)
treatment of malaria and associated symptoms. To evaluate the in vitro antiplasmodial efficacy and cytotoxic properties of indigenous medicinal plants used by Venda people against malaria. MATERIALS AND
Controlled human malaria infection leads to long-lasting changes in innate and innate-like lymphocyte populations (Publications)
clinically silent. To overcome this limitation, we examined blood samples from a controlled human malaria infection (CHMI) study in a Tanzanian cohort, in which volunteers underwent CHMI with a low or high
Bayesian spatio-temporal modeling of mortality in relation to malaria incidence in western Kenya (Publications)
between malaria transmission intensity and all-cause/malaria mortality. This offers a quick and efficient way to monitor malaria burden. Excess mortality estimates indicate that small changes in malaria incidence [...] spatio-temporal survival models to investigate the relation between mortality (all-cause/malaria-specific) and malaria incidence across all age groups. The analysis adjusted for insecticide-treated net (ITN) [...] positive association with malaria-specific mortality in young...
Tracking development assistance and government health expenditures for 35 malaria-eliminating countries: 1990-2017 (Publications)
financier for malaria, providing 96% of the total external funding for malaria in 2013, with vector control interventions being the highest cost driver in all regions. Government expenditure on malaria, while [...] health to the 35 countries actively pursuing malaria elimination. Where possible, development assistance for health (DAH) was categorized by spend on malaria intervention. A diverse set of data points were [...] were used to estimate government health budgets expenditure on malaria,...
Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection (Publications)
infection and is linked to severe disease and organ-specific pathology including cerebral and placental malaria. Immature gametocytes - sexual stage precursor cells - likewise disappear from circulation. Recent
Estimation of malaria parasite reservoir coverage using reactive case detection and active community fever screening from census data with rapid... (Publications)
areas where malaria transmission has been suppressed by vector control interventions many malaria control and elimination programmes are actively seeking new interventions to further reduce malaria prevalence [...] prevalence, incidence and transmission. Malaria infection prevalence and incidence has been shown to cluster geographically, especially at lower transmission levels, and as such a reactive strategy is frequently [...] infections than random searches, but this effect appears to be...
Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis (Publications)
criteria for defining severe malaria have evolved over the last 20 years. We aimed to assess the strength of association of death with features currently characterizing severe malaria through a systematic review [...] Web of Knowledge) were searched to identify publications including African children with severe malaria. PRISMA guidelines were followed. Selection was based on design (epidemiological, clinical and treatment [...] treatment studies), setting (Africa), participants (children < 15...
Haemoglobin changes and risk of anaemia following treatment for uncomplicated falciparum malaria in sub-Saharan Africa (Publications)
BACKGROUND: Anaemia is common in malaria. It is important to quantitate the risk of anaemia and to distinguish factors related to the natural history of disease from potential drug toxicity. METHODS: [...] data analysis based on nine randomized controlled trials of treatments of uncomplicated falciparum malaria from 13 sub-Saharan African countries. Risk factors for reduced haemoglobin (Hb) concentrations and
Natural immune response to <em>Plasmodium vivax </em>alpha-helical coiled coil protein motifs and its association with the risk of <em>P. vivax</em>... (Publications)
selected coiled coil antigens might be good markers of both exposure and acquired immunity to P. vivax malaria, and further preclinical investigation should be performed to determine their potential as P. vivax