Exploring early sexual differentiation in the malaria parasite Plasmodium falciparum (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/exploring-early-sexual-differentiation-in-the-malaria-parasite-plasmodium-falciparum
Apicomplexa, is the causative agent of the most severe form of malaria in humans. Despite the massive implementation of control interventions, malaria still causes over 200 million clinical cases and half a million [...] million deaths annually. The widespread prevalence of malaria in endemic regions is maintained by a complex yet highly efficient transmission cycle between the human host and mosquito vector. For transmission [...] gametocyte biology will be essential to support the development...
Combining sociological, economic and epidemiological evidence to target malaria interventions in Papua New Guinea and beyond (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/combining-sociological-economic-and-epidemiological-evidence-to-target-malaria-interventions-in-papua-new-guinea-and-beyond
interventions. However, current recommendations focus exclusively on stratification by malaria risk. Yet, malaria is multi-factorial and the impact of interventions in a given setting also depends on [...] conceptual framework for a multi-dimensional malaria stratification beyond mere epidemiological indicators. Papua New Guinea (PNG) with its complex malaria epidemiology serves as a model country. Project [...] To improve the (cost-) effectiveness of malaria control and accelerate progress...
Environmental, Social, Economic and Health Impact Assessment (ESHIA) for a Field Study of a Self-Limiting Nondrive Strain of Genetically Modified... (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/environmental-social-economic-and-health-impact-assessment-eshia-for-a-field-study-of-a-self-limiting-nondrive-strain-of-genetically-modified-mosquitoes-on-behalf-of-target-malaria
Genetically modified mosquitoes (GMMs) represent great potential for malaria control in the future. Target Malaria – a vector control research alliance based at the Imperial College in London – aims to [...] develop genetic technologies to modify mosquitoes with the ultimate goal to reduce malaria transmission. Target Malaria uses a three-phased approach in this 170-million project funded by the Bill and Melinda
Characterization of field malaria isolates and assessment of the impact of resistance profile on the transmission of resistant strains (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/characterization-of-field-malaria-isolates-and-assessment-of-the-impact-of-resistance-profile-on-the-transmission-of-resistant-strains
field malaria parasites, in order to provide a more realistic representation of malaria transmission occurring in natural settings. We will establish a continuous culture protocol for field malaria parasite [...] Health Institute (IHI, Tanzania). Malaria elimination is threatened by resistance to current insecticides and antimalarials. Developing novel technologies that target malaria transmission, such as transmission [...] transmission blocking drugs, vaccines or insecticides to control malari...
Evaluation of the Community-Based Malaria Surveillance and Response in Rwanda (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/evaluation-of-the-community-based-malaria-surveillance-and-response-in-rwanda
sustaining malaria elimination. Today, most of malaria control strategies rely on passive case detection through health facilities and CHWs. This passive case detection forms the foundation of malaria surveillance [...] approach will help Rwanda malaria control program to improve the deployment of interventions, and ultimately sustain the gains in malaria declines towards the achievement of malaria elimination in Rwanda. [...] proportion of malaria infections will not take the attention of...
PATH - MVI Malaria Vaccine Modeling: Service Agreement (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/path-mvi-malaria-vaccine-modeling-service-agreement
Swiss TPH is carrying out simulations of the public health impact of the RTS,S malaria vaccine, with the support of PATH-MVI. The work involves simulation of the impact of adding vaccines in the context [...] countries in sub-Saharan Africa, taking into account contextual factors such as the distributions of malaria transmission intensities. Vaccine profiles are based on field data from Phase III trials of RTS,S
Exploring seasonal malaria transmission dynamics and patterns of drug resistance: a molecular epidemiology study in two border areas of Côte d'Ivoire... (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/exploring-seasonal-malaria-transmission-dynamics-and-patterns-of-drug-resistance-a-molecular-epidemiology-study-in-two-border-areas-of-cote-divoire-and-burkina-faso
Health Organization (WHO) recommended seasonal malaria chemoprevention (SMC) in areas of high seasonal malaria transmission in the Sahel subregion to prevent malaria in children under five years of age. Burkina [...] the ten countries with the highest malaria burden in the world. Transmission in Burkina Faso and northern Côte d’Ivoire is highly seasonal and intense. In general, malaria infections peak during the wet season [...] during the dry season, which is largely unsuitable for malaria...
Global Malaria Technical & Training Support Package, Phase 4 (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/global-malaria-technical-training-support-package-phase-4
control, case management (malaria treatment) and cross-sectoral action against malaria, and through the training of malaria affected countries’ scientists and national malaria control managers. GlobMal [...] strategic direction towards the ambitious 2030 malaria goals to reduce malaria mortality by 40% by 2020 (compared with 2015) and to increase the number of malaria-free countries by additional 10 and 35 countries [...] contribute to global malaria control and elimination by shaping global and...
Provision of a Scoping Study for a Strategic Environmental Assessment (SEA) on behalf of Target Malaria (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/provision-of-a-scoping-study-for-a-strategic-environmental-assessment-sea-on-behalf-of-target-malaria
Genetically modified mosquitoes represent great potential for malaria control. Any future application of gene drive mosquitoes for malaria control will require many elements, including policy action, [...] to suppress populations of malaria vector mosquitoes. The assessments main objectives are to: (i) raise awareness amongst policy makers of genetic control tools for malaria using gene drives (ii) develop [...] gene drive (the action) and subsequent reduction of malaria (the desired effect)...
Clinical Performance Evaluation and Cost-Effectiveness Analysis of miLab platform for Supporting Malaria Control in Target Countries (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/clinical-performance-evaluation-and-cost-effectiveness-analysis-of-milab-platform-for-supporting-malaria-control-in-target-countries
samples. The platform is of potential high interested for malaria control, namely malaria diagnostics in low- and middle-income countries, as malaria remains a major cause of morbidity and mortality in large [...] compared to the current routine malaria diagnostic in the field. The impact evaluation will also assess whether and how the use of miLab contributes to an improved malaria case detection workflow in two