Pyrimethamine-resistant <em>Plasmodium falciparum</em> parasites among Tanzanian children: a facility-based study using the polymerase chain reaction (Publications)
of the 21 children with clinical malaria had pyrimethamine-resistant parasites. Currently, sulfadoxine-pyrimethamine is considered a potential first-line drug for malaria treatment in most African countries [...] used to estimate the proportion of pyrimethamine-resistant parasites in 101 children reporting with malaria at the hospital in Ifakara, a town in southern Tanzania. The method is based on the observation that [...] suggest that although sulfadoxine-pyrimethamine could still be effective...
Natacha Protopopoff (People)
https://www.swisstph.ch/fr/staff/profile/people/natacha-protopopoff
address gaps in malaria intervention coverage, including for primary and secondary school-aged children. These efforts aim to enhance protection for populations often underserved by current malaria control measures [...] managing large-scale vector control projects. Her research focuses on implementing and evaluating malaria control interventions, including the next generation of long-lasting insecticidal nets. Her expertise [...] Her previous employment includes positions at the London School...
High levels of genetic diversity of <em>Plasmodium falciparum</em> populations in Papua New Guinea despite variable infection prevalence (Publications)
obstacle to malaria control. Here, we investigate the relationship between local variation in malaria epidemiology and parasite genetic diversity in Papua New Guinea (PNG). Cross-sectional malaria surveys [...] surveys were performed in 14 villages spanning four distinct malaria-endemic areas on the north coast, including one area that was sampled during the dry season. High-resolution msp2 genotyping of 2,147 blood
Aktueller Malariaschutz bei Kurzzeitaufenthalt (Publications)
average of 800 malaria cases are recorded annually in Germany. One person in a hundred dies of the disease. Travel advice given by experienced physicians is essential to raise awareness of malaria risk in endemic [...] endemic areas. Rational mosquito protection on skin and textiles reduces the risk of malaria and other arthropod-transmitted diseases (e. g. dengue fever). Regular intake of an antimalarial drugs to suppress [...] doctor after taking the SET as quickly as possible. These elements...
High levels of genetic diversity of <em>Plasmodium falciparum</em> populations in Papua New Guinea despite variable infection prevalence (Publications)
obstacle to malaria control. Here, we investigate the relationship between local variation in malaria epidemiology and parasite genetic diversity in Papua New Guinea (PNG). Cross-sectional malaria surveys [...] surveys were performed in 14 villages spanning four distinct malaria-endemic areas on the north coast, including one area that was sampled during the dry season. High-resolution msp2 genotyping of 2,147 blood
Aktueller Malariaschutz bei Kurzzeitaufenthalt (Publications)
average of 800 malaria cases are recorded annually in Germany. One person in a hundred dies of the disease. Travel advice given by experienced physicians is essential to raise awareness of malaria risk in endemic [...] endemic areas. Rational mosquito protection on skin and textiles reduces the risk of malaria and other arthropod-transmitted diseases (e. g. dengue fever). Regular intake of an antimalarial drugs to suppress [...] doctor after taking the SET as quickly as possible. These elements...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
known as MMV1557817, and show that it targets multiple stages of the malaria parasite lifecycle, is active in a preliminary mouse malaria model, and has a novel mechanism of action. Excitingly, resistance [...] To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor [...] digestion in asexual parasites. MMV1557817 can kill sexual-stage P....
Spatial effects on the multiplicity of <em>Plasmodium falciparum</em> infections (Publications)
homogeneous transmission used in mathematical transmission models for malaria. In the present study an individual-based mathematical malaria transmission model that incorporates multiple parasite clones, variable [...] prevalence or multiplicity of infection (MOI). In traditionally highly malaria endemic regions where most of the population harbours malaria parasites, humans are often infected with multiple parasite clones [...] As malaria is being pushed back on many frontiers and global case...
