High levels of genetic diversity of <em>Plasmodium falciparum</em> populations in Papua New Guinea despite variable infection prevalence (Publications)
obstacle to malaria control. Here, we investigate the relationship between local variation in malaria epidemiology and parasite genetic diversity in Papua New Guinea (PNG). Cross-sectional malaria surveys [...] surveys were performed in 14 villages spanning four distinct malaria-endemic areas on the north coast, including one area that was sampled during the dry season. High-resolution msp2 genotyping of 2,147 blood
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
known as MMV1557817, and show that it targets multiple stages of the malaria parasite lifecycle, is active in a preliminary mouse malaria model, and has a novel mechanism of action. Excitingly, resistance [...] To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor [...] digestion in asexual parasites. MMV1557817 can kill sexual-stage P....
Spatial effects on the multiplicity of <em>Plasmodium falciparum</em> infections (Publications)
homogeneous transmission used in mathematical transmission models for malaria. In the present study an individual-based mathematical malaria transmission model that incorporates multiple parasite clones, variable [...] prevalence or multiplicity of infection (MOI). In traditionally highly malaria endemic regions where most of the population harbours malaria parasites, humans are often infected with multiple parasite clones [...] As malaria is being pushed back on many frontiers and global case...
The relative roles of ANC and EPI in the continuous distribution of LLINs: a qualitative study in four countries (Publications)
through EPI because of a) stronger linkages and involvement between malaria and reproductive health programmes, as compared to malaria and EPI, and b) more complete programme monitoring for ANC-based d [...] Background: The continuous distribution of long-lasting insecticidal nets (LLINs) for malaria prevention, through the antenatal care (ANC) and the Expanded Programme on Immunizations (EPI), is recommended [...] sub-national, and facility-level health staff, and were selected to capture a...
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
known as MMV1557817, and show that it targets multiple stages of the malaria parasite lifecycle, is active in a preliminary mouse malaria model, and has a novel mechanism of action. Excitingly, resistance [...] To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor [...] digestion in asexual parasites. MMV1557817 can kill sexual-stage P....
PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults (Publications)
stage malaria vaccine candidate based on whole, radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), has proven safe and effective in mediating sterile protection from malaria in malaria-naïve [...] underexplored, target for vaccine-induced antibodies in malaria pre-exposed volunteers. FUNDING: This work was supported by the Equatorial Guinea Malaria Vaccine Initiative (EGMVI), the Clinical Trial Platform [...] , we profiled IgG and IgM responses to PfSPZ Vaccine and subsequent...
The relative roles of ANC and EPI in the continuous distribution of LLINs: a qualitative study in four countries (Publications)
through EPI because of a) stronger linkages and involvement between malaria and reproductive health programmes, as compared to malaria and EPI, and b) more complete programme monitoring for ANC-based d [...] Background: The continuous distribution of long-lasting insecticidal nets (LLINs) for malaria prevention, through the antenatal care (ANC) and the Expanded Programme on Immunizations (EPI), is recommended [...] sub-national, and facility-level health staff, and were selected to capture a...
Spatial effects on the multiplicity of <em>Plasmodium falciparum</em> infections (Publications)
homogeneous transmission used in mathematical transmission models for malaria. In the present study an individual-based mathematical malaria transmission model that incorporates multiple parasite clones, variable [...] prevalence or multiplicity of infection (MOI). In traditionally highly malaria endemic regions where most of the population harbours malaria parasites, humans are often infected with multiple parasite clones [...] As malaria is being pushed back on many frontiers and global case...
