Discovery and structure-activity relationships of quinazolinone-2-carboxamide derivatives as novel orally efficacious antimalarials (Publications)
against laboratory-resistant strains of malaria. Profiling of 19f suggested a fast in vitro killing profile. In vivo activity in a murine model of human malaria in a dose-dependent manner constitutes a
Health information given by Swiss travel agencies (Publications)
agents mentioned preventive measures against malaria, but only 69% indicated the need for vaccinations against other diseases. Spontaneous advice on malaria risk and vaccinations was better than advice [...] through travel agencies every year. These agencies are thus an important source of information about malaria and other important health risks and little is known about the appropriate health information provided [...] advice given upon prompting. One fifth of all travel agents neither...
Indigenous emergence and spread of <em>kelch13</em> C469Y artemisinin-resistant <em>Plasmodium falciparum</em> in Uganda (Publications)
As part of the Community Access to Rectal Artesunate for Malaria project, we collected blood samples from 697 children with signs of severe malaria in northern Uganda between 2018 and 2020, before and after [...] Artemisinin-based combination therapies (ACTs) were introduced as the standard of care for uncomplicated malaria in Africa almost two decades ago. Recent studies in East Africa have reported a gradual increase [...] geographic origin of k13 mutations. Of the 697 children, 540 were...
Following in Soper's footsteps: northeast Brazil 63 years after eradication of <em>Anopheles gambiae</em> (Publications)
years ago was a new and horrifying experience. This African mosquito is an exceptionally effective malaria vector because it is well adapted to feeding upon people and to exploiting aquatic habitats associated [...] with our daily activities. Anopheles gambiae sensu lato probably accounts for most of the world's malaria deaths and socioeconomic burden. Fortunately, the Brazilian experience had a happy ending. The prospect [...] aegypti elimination, the Rockefeller Foundation and Brazilian...
Spatially-explicit risk profiling of<em> Plasmodium falciparum</em> infections at a small scale: a geostatistical modelling approach (Publications)
BACKGROUND: There is a renewed political will and financial support to eradicate malaria. Spatially-explicit risk profiling will play an important role in this endeavour. Patterns of Plasmodium falciparum [...] falciparum infection prevalence were examined among schoolchildren in a highly malaria-endemic area. METHODS: A questionnaire was administered and finger prick blood samples collected from 3,962 children, aged [...] the questionnaire on children's socioeconomic status and the use of bed...
Following in Soper's footsteps: northeast Brazil 63 years after eradication of <em>Anopheles gambiae</em> (Publications)
years ago was a new and horrifying experience. This African mosquito is an exceptionally effective malaria vector because it is well adapted to feeding upon people and to exploiting aquatic habitats associated [...] with our daily activities. Anopheles gambiae sensu lato probably accounts for most of the world's malaria deaths and socioeconomic burden. Fortunately, the Brazilian experience had a happy ending. The prospect [...] aegypti elimination, the Rockefeller Foundation and Brazilian...
Health information given by Swiss travel agencies (Publications)
agents mentioned preventive measures against malaria, but only 69% indicated the need for vaccinations against other diseases. Spontaneous advice on malaria risk and vaccinations was better than advice [...] through travel agencies every year. These agencies are thus an important source of information about malaria and other important health risks and little is known about the appropriate health information provided [...] advice given upon prompting. One fifth of all travel agents neither...
Indigenous emergence and spread of <em>kelch13</em> C469Y artemisinin-resistant <em>Plasmodium falciparum</em> in Uganda (Publications)
As part of the Community Access to Rectal Artesunate for Malaria project, we collected blood samples from 697 children with signs of severe malaria in northern Uganda between 2018 and 2020, before and after [...] Artemisinin-based combination therapies (ACTs) were introduced as the standard of care for uncomplicated malaria in Africa almost two decades ago. Recent studies in East Africa have reported a gradual increase [...] geographic origin of k13 mutations. Of the 697 children, 540 were...
Spatially-explicit risk profiling of<em> Plasmodium falciparum</em> infections at a small scale: a geostatistical modelling approach (Publications)
BACKGROUND: There is a renewed political will and financial support to eradicate malaria. Spatially-explicit risk profiling will play an important role in this endeavour. Patterns of Plasmodium falciparum [...] falciparum infection prevalence were examined among schoolchildren in a highly malaria-endemic area. METHODS: A questionnaire was administered and finger prick blood samples collected from 3,962 children, aged [...] the questionnaire on children's socioeconomic status and the use of bed...
Mathematical modelling to examine disease, control measures, vaccine interactions and resistance to guide public health and disease elimination... (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/mathematical-modelling-to-examine-disease-control-measures-vaccine-interactions-and-resistance-to-guide-public-health-and-disease-elimination-strategies
resistance to disease interventions. We address two important pathogens: malaria and SARS-Cov-2. As we get closer to eliminating malaria and other diseases, preventing diseases from evolving resistance to response [...] detailed parasite models, mosquito-to-human transmission models and adapt individual-level models for malaria. We will also adapt models of SARS-CoV-2 to examine the emergence of vaccine-resistant COVID variants [...] pathogens. We will examine resistance to vaccines, drugs and...
