Lack of associations of alpha(+) - thalassemia with the risk of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infection and disease in... (Publications)
unknown. An increase in risk of Plasmodium vivax malaria in early childhood resulting in a cross-species protection against severe P. falciparum malaria has been proposed as a possible mechanism in Melanesian [...] wild-type allele. No significant differences in the incidence of P. falciparum (Pf) or P. vivax (Pv) malaria were observed between alpha(+)-thalassemia homozygote (Pf: Incidence rate ratio (IRR) = 1.13, CI(95) [...] = 0.008). This study therefore failed to confirm an increased risk of...
Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on... (Publications)
and killing effects of LLINs on both susceptible and pyrethroid resistant malaria vectors to estimate the protection against malaria transmission-in terms of vectorial capacity (VC)-provided by each net cohort [...] BACKGROUND: Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under [...] contributions of these different interrelated factors to durability of...
Two cases of long‑lasting, sub‑microscopic <em>Plasmodium malariae</em> infections in adults from coastal Tanzania (Publications)
symptoms. The presented data also demonstrate that clinical study sites in malaria endemic regions need to have a strong malaria diagnostic infrastructure, including the ability of capturing sub-microscopic [...] BACKGROUND: Malaria is endemic in Tanzania with majority of clinical cases caused by Plasmodium falciparum. Additionally, Plasmodium malariae and Plasmodium ovale spp. are also present and clinical ma [...] P. malariae infections that were identified during a clinical trial evaluating...
Design, implementation and evaluation of a national campaign to deliver 18 million free long-lasting insecticidal nets to uncovered sleeping spaces in... (Publications)
chiefly financed by the Global Fund to Fight AIDS, Tuberculosis and Malaria with important contributions from the US President's Malaria Initiative. A total of 18.2 million LLINs were delivered at an average [...] through previous initiatives.METHODS: The UCC was coordinated through a unit within the National Malaria Control Programme. Partners were contracted by the MoHSW to implement different activities in co [...] delivery and 17% for campaign associated activities. Preliminary results of...
Limited antigenic diversity of <em>Plasmodium falciparum</em> apical membrane antigen 1 supports the development of effective multi-allele vaccines (Publications)
evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge [...] falciparum apical membrane antigen 1 (AMA1) is an important target of naturally-acquired antibodies in malaria immunity and a leading vaccine candidate. However, AMA1 has extensive allelic diversity with more [...] single population. Therefore, AMA1 serves as an excellent model to assess...
Ultra-sensitive detection of <em>Plasmodium falciparum</em> by amplification of multi-copy subtelomeric targets (Publications)
qPCR in community surveillance and for monitoring interventions to better describe malaria epidemiology and inform malaria elimination efforts [...] BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be [...] might still remain undetected when absent in the limited blood volume sampled. CONCLUSIONS: Measured malaria prevalence in communities is...
Design, implementation and evaluation of a national campaign to deliver 18 million free long-lasting insecticidal nets to uncovered sleeping spaces in... (Publications)
chiefly financed by the Global Fund to Fight AIDS, Tuberculosis and Malaria with important contributions from the US President's Malaria Initiative. A total of 18.2 million LLINs were delivered at an average [...] through previous initiatives.METHODS: The UCC was coordinated through a unit within the National Malaria Control Programme. Partners were contracted by the MoHSW to implement different activities in co [...] delivery and 17% for campaign associated activities. Preliminary results of...
Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on... (Publications)
and killing effects of LLINs on both susceptible and pyrethroid resistant malaria vectors to estimate the protection against malaria transmission-in terms of vectorial capacity (VC)-provided by each net cohort [...] BACKGROUND: Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under [...] contributions of these different interrelated factors to durability of...
Ultra-sensitive detection of <em>Plasmodium falciparum</em> by amplification of multi-copy subtelomeric targets (Publications)
qPCR in community surveillance and for monitoring interventions to better describe malaria epidemiology and inform malaria elimination efforts [...] BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be [...] might still remain undetected when absent in the limited blood volume sampled. CONCLUSIONS: Measured malaria prevalence in communities is...
Lack of associations of alpha(+) - thalassemia with the risk of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infection and disease in... (Publications)
unknown. An increase in risk of Plasmodium vivax malaria in early childhood resulting in a cross-species protection against severe P. falciparum malaria has been proposed as a possible mechanism in Melanesian [...] wild-type allele. No significant differences in the incidence of P. falciparum (Pf) or P. vivax (Pv) malaria were observed between alpha(+)-thalassemia homozygote (Pf: Incidence rate ratio (IRR) = 1.13, CI(95) [...] = 0.008). This study therefore failed to confirm an increased risk of...