Ultra-sensitive detection of <em>Plasmodium falciparum</em> by amplification of multi-copy subtelomeric targets (Publications)
qPCR in community surveillance and for monitoring interventions to better describe malaria epidemiology and inform malaria elimination efforts [...] BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be [...] might still remain undetected when absent in the limited blood volume sampled. CONCLUSIONS: Measured malaria prevalence in communities is...
Lack of associations of alpha(+) - thalassemia with the risk of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infection and disease in... (Publications)
unknown. An increase in risk of Plasmodium vivax malaria in early childhood resulting in a cross-species protection against severe P. falciparum malaria has been proposed as a possible mechanism in Melanesian [...] wild-type allele. No significant differences in the incidence of P. falciparum (Pf) or P. vivax (Pv) malaria were observed between alpha(+)-thalassemia homozygote (Pf: Incidence rate ratio (IRR) = 1.13, CI(95) [...] = 0.008). This study therefore failed to confirm an increased risk of...
Two cases of long‑lasting, sub‑microscopic <em>Plasmodium malariae</em> infections in adults from coastal Tanzania (Publications)
symptoms. The presented data also demonstrate that clinical study sites in malaria endemic regions need to have a strong malaria diagnostic infrastructure, including the ability of capturing sub-microscopic [...] BACKGROUND: Malaria is endemic in Tanzania with majority of clinical cases caused by Plasmodium falciparum. Additionally, Plasmodium malariae and Plasmodium ovale spp. are also present and clinical ma [...] P. malariae infections that were identified during a clinical trial evaluating...
Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on... (Publications)
and killing effects of LLINs on both susceptible and pyrethroid resistant malaria vectors to estimate the protection against malaria transmission-in terms of vectorial capacity (VC)-provided by each net cohort [...] BACKGROUND: Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under [...] contributions of these different interrelated factors to durability of...
Design, implementation and evaluation of a national campaign to deliver 18 million free long-lasting insecticidal nets to uncovered sleeping spaces in... (Publications)
chiefly financed by the Global Fund to Fight AIDS, Tuberculosis and Malaria with important contributions from the US President's Malaria Initiative. A total of 18.2 million LLINs were delivered at an average [...] through previous initiatives.METHODS: The UCC was coordinated through a unit within the National Malaria Control Programme. Partners were contracted by the MoHSW to implement different activities in co [...] delivery and 17% for campaign associated activities. Preliminary results of...
Limited antigenic diversity of <em>Plasmodium falciparum</em> apical membrane antigen 1 supports the development of effective multi-allele vaccines (Publications)
evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge [...] falciparum apical membrane antigen 1 (AMA1) is an important target of naturally-acquired antibodies in malaria immunity and a leading vaccine candidate. However, AMA1 has extensive allelic diversity with more [...] single population. Therefore, AMA1 serves as an excellent model to assess...
Ultra-sensitive detection of <em>Plasmodium falciparum</em> by amplification of multi-copy subtelomeric targets (Publications)
qPCR in community surveillance and for monitoring interventions to better describe malaria epidemiology and inform malaria elimination efforts [...] BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be [...] might still remain undetected when absent in the limited blood volume sampled. CONCLUSIONS: Measured malaria prevalence in communities is...
Spatial epidemiology of urban health risks in select West African cities (Publications)
epidemiology of diarrhaea and malaria, and their associated risks factors in the following select West African cities. Spatial variability of exposure to diarrhaea and malaria transmission is linked to several
Use of antibiotics within the IMCI guidelines in outpatient settings in Papua New Guinean children: an observational and effectiveness study (Publications)
routine outpatient clinics. METHODS: Making use of a passive case detection system established for a malaria prevention trial in outpatient clinics in Papua New Guinea, the appropriateness and effectiveness [...] antibiotics and re-attendances within 14 days for mild pneumonia, mild diarrhoea and uncomplicated malaria whether they were managed with or without antibiotics (proxy of effectiveness). Appropriateness was
Clara Champagne (People)
https://www.swisstph.ch/fr/staff/profile/people/clara-champagne
Intervention Modelling group to provide country specific modelling support for decision making on malaria interventions. Her recent work includes P. vivax modelling with applications in Central America and [...] health workers geographical placement. She has also participated in the modelling work supporting malaria control programmes within the HBHI initiative. Complete publication list available on Google Scholar