Urban agriculture and <em>Anopheles</em> habitats in Dar es Salaam, Tanzania (Publications)
than a fifth of all breeding sites of malaria vectors in Dar es Salaam. It is suggested that strategies comprising an integrated malaria control effort in malaria-endemic African cities include participatory
Spatial distribution of the chromosomal forms of <em>anopheles gambiae</em> in Mali (Publications)
BACKGROUND: Maps of the distribution of malaria vectors are useful tools for stratification of malaria risk and for selective vector control strategies. Although the distribution of members of the Anopheles [...] (insecticide resistance management) and may serve as a decision support tool for the basis for future malaria control strategies including genetically manipulated mosquitoes
Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
Amodiaquine plus artesunate is the recommended antimalarial treatment in many malaria-endemic countries. However, pediatric doses are largely based on a linear extrapolation from adult doses. We pooled [...] amodiaquine, to optimize the dose across all age groups. Adults and children with uncomplicated malaria received daily weight-based doses of amodiaquine or artesunate-amodiaquine over three days. Plasma [...] 22.4% (15.6 - 31.9%) lower at the start of treatment than during convalescence,...
Comparative study of the effects of artemether and artesunate on juvenile and adult<em> Schistosoma mansoni</em> in experimentally infected mice (Publications)
stages of schistosome parasites. Since artemisinin derivatives will be increasingly used to treat malaria, it is important to study the effects of 7-day monotherapy regimens on schistosome infections. We [...] artemether or artesunate at various doses and regimens including those currently used for monotherapy of malaria. Three doses of artemether, at concentrations of 150 or 300 mg/kg, administered to mice with juvenile [...] discussions on the effect and use of artemisinin derivatives against...
The mode of action of spatial repellents and their impact on vectorial capacity of<em> Anopheles gambiae sensu stricto</em> (Publications)
Malaria vector control relies on toxicity of insecticides used in long lasting insecticide treated nets and indoor residual spraying. This is despite evidence that sub-lethal insecticides reduce human-vector [...] human-vector contact and malaria transmission. The impact of sub-lethal insecticides on host seeking and blood feeding of mosquitoes was measured. Taxis boxes distinguished between repellency and attraction [...] target product profiles of spatial repellent products that can be used to...
Innovative tools and OpenHDS for health and demographic surveillance on Rusinga Island, Kenya (Publications)
METHODS: A large trial investigating the effect of odour-baited mosquito traps on malaria vector populations and malaria transmission on Rusinga Island, western Kenya, has deployed an HDSS. By means of [...] DISCUSSION: Adopting innovative technological advancements has enabled the collection of demographic and malaria data quickly and effectively, with minimal margin for errors. Real-time data quality controls integrated
Urban agriculture and <em>Anopheles</em> habitats in Dar es Salaam, Tanzania (Publications)
than a fifth of all breeding sites of malaria vectors in Dar es Salaam. It is suggested that strategies comprising an integrated malaria control effort in malaria-endemic African cities include participatory
<em>Plasmodium falciparum</em> merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic... (Publications)
allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates. The aim of the current study is to characterize the immune response (epitope [...] (epitope mapping) in naturally exposed individuals and relate immune responses to the risk of clinical malaria. METHODS: To optimize their construction, the fine specificity of human serum antibodies from donors [...] response to individual epitopes within the 3D7 family-specific region...
Asymptomatic <em>Plasmodium</em> infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire (Publications)
associations of Plasmodium infection (PI) with fasting glucose (FG) and glycated hemoglobin (HbA1c) in malaria-endemic south-central Cote d'Ivoire. METHODS: We studied 979 participants (non-pregnant; no treated [...] Fasting venous blood was obtained for PI, FG, and HbA1c assessment. We defined PI as a positive malaria rapid diagnostic test (RDT) or microscopic identification of Plasmodium species. We applied multivariable [...] diagnosis in the presence of asymptomatic PI may misclassify or...
Semi-field evaluation of a volatile transfluthrin-based intervention reveals efficacy as a spatial repellent and evidence of other modes of action (Publications)
Presently, the most common malaria control tools-i.e., long lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS)-are limited to targeting indoor biting and resting behaviors of Anopheles [...] Anopheles mosquito species. Few interventions are targeted towards malaria control in areas where transmission is driven or persists due to outdoor biting behaviors. This study investigated a volatile [...] Southern Province, Zambia, is one such environment where outdoor biting is...